Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553276489> ?p ?o ?g. }
- W2553276489 endingPage "886" @default.
- W2553276489 startingPage "872" @default.
- W2553276489 abstract "Amino acids are essential for proper growth and development in plants. Amino acids serve as building blocks for proteins but also are important for responses to stress and the biosynthesis of numerous essential compounds. In seed, the pool of free amino acids (FAAs) also contributes to alternative energy, desiccation, and seed vigor; thus, manipulating FAA levels can significantly impact a seed's nutritional qualities. While genome-wide association studies (GWAS) on branched-chain amino acids have identified some regulatory genes controlling seed FAAs, the genetic regulation of FAA levels, composition, and homeostasis in seeds remains mostly unresolved. Hence, we performed GWAS on 18 FAAs from a 313-ecotype Arabidopsis (Arabidopsis thaliana) association panel. Specifically, GWAS was performed on 98 traits derived from known amino acid metabolic pathways (approach 1) and then on 92 traits generated from an unbiased correlation-based metabolic network analysis (approach 2), and the results were compared. The latter approach facilitated the discovery of additional novel metabolic interactions and single-nucleotide polymorphism-trait associations not identified by the former approach. The most prominent network-guided GWAS signal was for a histidine (His)-related trait in a region containing two genes: a cationic amino acid transporter (CAT4) and a polynucleotide phosphorylase resistant to inhibition with fosmidomycin. A reverse genetics approach confirmed CAT4 to be responsible for the natural variation of His-related traits across the association panel. Given that His is a semiessential amino acid and a potent metal chelator, CAT4 orthologs could be considered as candidate genes for seed quality biofortification in crop plants." @default.
- W2553276489 created "2016-11-30" @default.
- W2553276489 creator A5001644139 @default.
- W2553276489 creator A5031658549 @default.
- W2553276489 creator A5036750502 @default.
- W2553276489 creator A5037889583 @default.
- W2553276489 creator A5082281381 @default.
- W2553276489 creator A5087622706 @default.
- W2553276489 creator A5087661999 @default.
- W2553276489 date "2016-11-21" @default.
- W2553276489 modified "2023-10-12" @default.
- W2553276489 title "Network-Guided GWAS Improves Identification of Genes Affecting Free Amino Acids" @default.
- W2553276489 cites W1900646844 @default.
- W2553276489 cites W1946024497 @default.
- W2553276489 cites W1966052950 @default.
- W2553276489 cites W1966338143 @default.
- W2553276489 cites W1969790498 @default.
- W2553276489 cites W1971429640 @default.
- W2553276489 cites W1981409633 @default.
- W2553276489 cites W2002900187 @default.
- W2553276489 cites W2008147924 @default.
- W2553276489 cites W2009749555 @default.
- W2553276489 cites W2011512348 @default.
- W2553276489 cites W2013465714 @default.
- W2553276489 cites W2016261843 @default.
- W2553276489 cites W2017547171 @default.
- W2553276489 cites W2021085327 @default.
- W2553276489 cites W2029483604 @default.
- W2553276489 cites W2030444684 @default.
- W2553276489 cites W2032457672 @default.
- W2553276489 cites W2032700288 @default.
- W2553276489 cites W2035864960 @default.
- W2553276489 cites W2038111222 @default.
- W2553276489 cites W2041284215 @default.
- W2553276489 cites W2042040184 @default.
- W2553276489 cites W2046115898 @default.
- W2553276489 cites W2054211166 @default.
- W2553276489 cites W2054658528 @default.
- W2553276489 cites W2055399262 @default.
- W2553276489 cites W2068406373 @default.
- W2553276489 cites W2069288578 @default.
- W2553276489 cites W2072040767 @default.
- W2553276489 cites W2074783354 @default.
- W2553276489 cites W2080426060 @default.
- W2553276489 cites W2082695702 @default.
- W2553276489 cites W2083995085 @default.
- W2553276489 cites W2084482326 @default.
- W2553276489 cites W2084536510 @default.
- W2553276489 cites W2085141987 @default.
- W2553276489 cites W2086124278 @default.
- W2553276489 cites W2086372521 @default.
- W2553276489 cites W2087387473 @default.
- W2553276489 cites W2089032501 @default.
- W2553276489 cites W2090751865 @default.
- W2553276489 cites W2094275350 @default.
- W2553276489 cites W2100775857 @default.
- W2553276489 cites W2100999167 @default.
- W2553276489 cites W2102275335 @default.
- W2553276489 cites W2109077806 @default.
- W2553276489 cites W2109101919 @default.
- W2553276489 cites W2110349321 @default.
- W2553276489 cites W2110991923 @default.
- W2553276489 cites W2114045287 @default.
- W2553276489 cites W2116122104 @default.
- W2553276489 cites W2116272744 @default.
- W2553276489 cites W2119577108 @default.
- W2553276489 cites W2119719542 @default.
- W2553276489 cites W2120465937 @default.
- W2553276489 cites W2120521842 @default.
- W2553276489 cites W2120602587 @default.
- W2553276489 cites W2121914152 @default.
- W2553276489 cites W2123775894 @default.
- W2553276489 cites W2124084445 @default.
- W2553276489 cites W2124390519 @default.
- W2553276489 cites W2124522156 @default.
- W2553276489 cites W2125118217 @default.
- W2553276489 cites W2127003026 @default.
- W2553276489 cites W2128626650 @default.
- W2553276489 cites W2129135960 @default.
- W2553276489 cites W2131834848 @default.
- W2553276489 cites W2135307576 @default.
- W2553276489 cites W2137326400 @default.
- W2553276489 cites W2137797806 @default.
- W2553276489 cites W2138465900 @default.
- W2553276489 cites W2139775940 @default.
- W2553276489 cites W2142029963 @default.
- W2553276489 cites W2145083705 @default.
- W2553276489 cites W2146374090 @default.
- W2553276489 cites W2149582597 @default.
- W2553276489 cites W2152140530 @default.
- W2553276489 cites W2153236054 @default.
- W2553276489 cites W2153665389 @default.
- W2553276489 cites W2155060650 @default.
- W2553276489 cites W2157890214 @default.
- W2553276489 cites W2158547433 @default.
- W2553276489 cites W2158752901 @default.
- W2553276489 cites W2159400745 @default.
- W2553276489 cites W2159675211 @default.