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- W2553298032 abstract "The Werner syndrome protein (WRN) suppresses the loss of telomeres replicated by lagging-strand synthesis by a yet to be defined mechanism. Here, we show that whereas either WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase δ progression across telomeric G-rich repeats, only WRN promotes sequential strand displacement synthesis and FEN1 cleavage, a critical step in Okazaki fragment maturation, at these sequences. Helicase activity, as well as the conserved winged-helix (WH) motif and the helicase and RNase D C-terminal (HRDC) domain play important but distinct roles in this process. Remarkably, WRN also influences the formation of FEN1 cleavage products during strand displacement on a nontelomeric substrate, suggesting that WRN recruitment and cooperative interaction with FEN1 during lagging-strand synthesis may serve to regulate sequential strand displacement and flap cleavage at other genomic sites. These findings define a biochemical context for the physiological role of WRN in maintaining genetic stability." @default.
- W2553298032 created "2016-11-30" @default.
- W2553298032 creator A5025548879 @default.
- W2553298032 creator A5047044463 @default.
- W2553298032 creator A5048816559 @default.
- W2553298032 date "2017-02-01" @default.
- W2553298032 modified "2023-10-15" @default.
- W2553298032 title "The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation" @default.
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- W2553298032 cites W1973440927 @default.
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- W2553298032 doi "https://doi.org/10.1128/mcb.00560-16" @default.
- W2553298032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5247617" @default.
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- W2553298032 hasPublicationYear "2017" @default.
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