FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553343555> ?p ?o ?g. }

• W2553343555 abstract "What are the primary causes of severe male factor infertility? Although 40% of all patients showed primary causes of infertility, which could be subdivided into three groups based on the severity of their effect, ~75% of oligozoospermia cases remained idiopathic. There are few large-scale epidemiological studies analyzing the causes of male factor infertility. A prospective clinical-epidemiological study was conducted at the Andrology Centre, Tartu University Hospital between 2005 and 2013, recruiting male partners of couples failing to conceive a child for over ≥12 months. Among 8518 patients, 1737 (20.4%) were diagnosed with severe male factor infertility. A reference group of fertile controls was comprised of 325 partners of pregnant women. The mean age of infertility patients and fertile controls was 33.2 ± 7.3 and 31.7 ± 6.3 years, respectively. All participants were examined using a standardized andrology workup, accompanied by a structured medical interview. Hormonal analysis included serum FSH, LH and testosterone. Semen quality was determined in accordance to the World Health Organization recommendations. Cases with spermatozoa concentrations of ≤5 million/ml were screened for chromosomal aberrations and Y-chromosomal microdeletions. The primary cause of infertility was defined for 695 of 1737 patients (~40%). The analyzed causal factors could be divided into absolute (secondary hypogonadism, genetic causes, seminal tract obstruction), severe (oncological diseases, severe sexual dysfunction) and plausible causal factors (congenital anomalies in uro-genital tract, acquired or secondary testicular damage). The latter were also detected for 11 (3.4%) men with proven fertility (diagnoses: unilateral cryptorchidism, testis cancer, orchitis, mumps orchitis). The causal factors behind the most severe forms of impaired spermatogenesis were relatively well understood; causes were assigned: for aspermia in 46/46 cases (100%), for azoospermia in 321/388 cases (82.7%), and for cryptozoospermia in 54/130 cases (41.5%). In contrast, 75% of oligozoospermia cases remained unexplained. The main cause of aspermia was severe sexual dysfunction (71.7% of aspermia patients). Azoospermia patients accounted for 86.4% of all cases diagnosed with secondary hypogonadism and 97.1% of patients with seminal tract obstruction. Of patients with a known genetic factor, 87.4% had extreme infertility (azoo-, crypto- or aspermia). The prevalence of congenital anomalies in the uro-genital tract was not clearly correlated with the severity of impaired sperm production. Previously defined ‘potential contributing factors’ varicocele and leukocytospermia were excluded as the primary causes of male infertility. However, their incidence was >2-fold higher (31.0 vs 13.5% and 16.1 vs 7.4%; P < 0.001) in the idiopathic infertility group compared to controls. In addition, the proportions of overweight (or obese) patients and patients suffering from a chronic disease were significantly increased in almost all of the patient subgroups. The study included only subjects with reduced total spermatozoa counts. Thus, these findings cannot be automatically applied to all male factor infertility cases. The novel insights and improved clarity achieved in the comprehensive analysis regarding the absolute, causative and plausible factors behind male infertility, as well as the ‘potential contributing factors’, will be valuable tools in updating the current clinical guidelines. The study highlights knowledge gaps and reiterates an urgent need to uncover the causes and mechanisms behind, and potential treatments of, oligozoospermic cases, representing the majority of idiopathic infertility patients (86.3%). The project was financed by the EU through the ERDF, project HAPPY PREGNANCY, no. 3.2.0701.12-004 (M.P., M.L.) and the Estonian Research Council: grants PUT181 (M.P.) and IUT34-12 (M.L.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. We have no competing interests to declare. Not applicable" @default.
• W2553343555 created "2016-11-30" @default.
• W2553343555 creator A5023991273 @default.
• W2553343555 creator A5028788732 @default.
• W2553343555 creator A5034352318 @default.
• W2553343555 creator A5060382896 @default.
• W2553343555 creator A5070702985 @default.
• W2553343555 creator A5080896874 @default.
• W2553343555 creator A5081652641 @default.
• W2553343555 creator A5087965287 @default.
• W2553343555 date "2016-11-17" @default.
• W2553343555 modified "2023-10-06" @default.
• W2553343555 title "Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts" @default.
• W2553343555 cites W165315917 @default.
• W2553343555 cites W1791123973 @default.
• W2553343555 cites W1963888774 @default.
• W2553343555 cites W1976013921 @default.
• W2553343555 cites W1988020355 @default.
• W2553343555 cites W2005568203 @default.
• W2553343555 cites W2018607399 @default.
• W2553343555 cites W2050506010 @default.
• W2553343555 cites W2058148198 @default.
• W2553343555 cites W2069136536 @default.
• W2553343555 cites W2069277865 @default.
• W2553343555 cites W2113207118 @default.
• W2553343555 cites W2113393026 @default.
• W2553343555 cites W2120163876 @default.
• W2553343555 cites W2134765601 @default.
• W2553343555 cites W2147452407 @default.
• W2553343555 cites W2156400902 @default.
• W2553343555 cites W2166759291 @default.
• W2553343555 cites W2170773893 @default.
• W2553343555 cites W2176748923 @default.
• W2553343555 cites W2271239127 @default.
• W2553343555 cites W37591796 @default.
• W2553343555 cites W4233542142 @default.
• W2553343555 cites W4298228160 @default.
• W2553343555 cites W88135509 @default.
• W2553343555 doi "https://doi.org/10.1093/humrep/dew284" @default.
• W2553343555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5165077" @default.
• W2553343555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27864361" @default.
• W2553343555 hasPublicationYear "2016" @default.
• W2553343555 type Work @default.
• W2553343555 sameAs 2553343555 @default.
• W2553343555 citedByCount "150" @default.
• W2553343555 countsByYear W25533435552017 @default.
• W2553343555 countsByYear W25533435552018 @default.
• W2553343555 countsByYear W25533435552019 @default.
• W2553343555 countsByYear W25533435552020 @default.
• W2553343555 countsByYear W25533435552021 @default.
• W2553343555 countsByYear W25533435552022 @default.
• W2553343555 countsByYear W25533435552023 @default.
• W2553343555 crossrefType "journal-article" @default.
• W2553343555 hasAuthorship W2553343555A5023991273 @default.
• W2553343555 hasAuthorship W2553343555A5028788732 @default.
• W2553343555 hasAuthorship W2553343555A5034352318 @default.
• W2553343555 hasAuthorship W2553343555A5060382896 @default.
• W2553343555 hasAuthorship W2553343555A5070702985 @default.
• W2553343555 hasAuthorship W2553343555A5080896874 @default.
• W2553343555 hasAuthorship W2553343555A5081652641 @default.
• W2553343555 hasAuthorship W2553343555A5087965287 @default.
• W2553343555 hasBestOaLocation W25533435551 @default.
• W2553343555 hasConcept C107130276 @default.
• W2553343555 hasConcept C126322002 @default.
• W2553343555 hasConcept C131872663 @default.
• W2553343555 hasConcept C16685009 @default.
• W2553343555 hasConcept C188816634 @default.
• W2553343555 hasConcept C2777338322 @default.
• W2553343555 hasConcept C2777589648 @default.
• W2553343555 hasConcept C2777688143 @default.
• W2553343555 hasConcept C2778080409 @default.
• W2553343555 hasConcept C2778093475 @default.
• W2553343555 hasConcept C2779234561 @default.
• W2553343555 hasConcept C2779279991 @default.
• W2553343555 hasConcept C2908647359 @default.
• W2553343555 hasConcept C29456083 @default.
• W2553343555 hasConcept C42407357 @default.
• W2553343555 hasConcept C518429986 @default.
• W2553343555 hasConcept C54355233 @default.
• W2553343555 hasConcept C71924100 @default.
• W2553343555 hasConcept C86803240 @default.
• W2553343555 hasConcept C99454951 @default.
• W2553343555 hasConceptScore W2553343555C107130276 @default.
• W2553343555 hasConceptScore W2553343555C126322002 @default.
• W2553343555 hasConceptScore W2553343555C131872663 @default.
• W2553343555 hasConceptScore W2553343555C16685009 @default.
• W2553343555 hasConceptScore W2553343555C188816634 @default.
• W2553343555 hasConceptScore W2553343555C2777338322 @default.
• W2553343555 hasConceptScore W2553343555C2777589648 @default.
• W2553343555 hasConceptScore W2553343555C2777688143 @default.
• W2553343555 hasConceptScore W2553343555C2778080409 @default.
• W2553343555 hasConceptScore W2553343555C2778093475 @default.
• W2553343555 hasConceptScore W2553343555C2779234561 @default.
• W2553343555 hasConceptScore W2553343555C2779279991 @default.
• W2553343555 hasConceptScore W2553343555C2908647359 @default.
• W2553343555 hasConceptScore W2553343555C29456083 @default.
• W2553343555 hasConceptScore W2553343555C42407357 @default.
• W2553343555 hasConceptScore W2553343555C518429986 @default.
• W2553343555 hasConceptScore W2553343555C54355233 @default.
• W2553343555 hasConceptScore W2553343555C71924100 @default.

• next