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- W2553345498 abstract "The aim of this study was to find the effect of carbon nanotube functionalized with Morin molecule (CNTFM) on normal and mutant forms of amyloid precursor protein (APP), found in Alzheimer’s disease. In this study, one mutant and one normal APP were separately modeled in Hyperchem software. After minimization of system energy, molecular dynamic (MD) simulation was separately carried out for 30[Formula: see text]000[Formula: see text]ps in NVT ensemble at 310[Formula: see text]K. At the end of simulation, different parameters, such as free energy, intermolecular energy and root mean square displacement (RMSD) were separately monitored for each APP. Finally, the ratio of change was calculated for each parameter. To confirm simulation results, one mL of mutant APP (10 mM) was incubated with one mL of CNTFM (10[Formula: see text]mg/mL) for 1[Formula: see text]h. Finally, the percentages of the different secondary structures of both treated and untreated APP were separately estimated by FTIR analysis. Based on MD simulation, high ratio of change was seen for mutant APP. Experimental study showed that the proportion of [Formula: see text]-sheets (parallel [Formula: see text] anti-parallel) and random coil was decreased when incubated with CNTFM. Moreover, the proportion of [Formula: see text]-turns was increased. Interestingly, the proportion of [Formula: see text]-sheets (anti-parallel) was not changed." @default.
- W2553345498 created "2016-11-30" @default.
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- W2553345498 date "2017-03-01" @default.
- W2553345498 modified "2023-09-23" @default.
- W2553345498 title "Conformational Change of Mutant form of Amyloid Precursor Protein by Carbon Nanotube Functionalized with Morin" @default.
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- W2553345498 doi "https://doi.org/10.1142/s1793984417500015" @default.
- W2553345498 hasPublicationYear "2017" @default.
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