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- W2553351021 abstract "<b>Introduction:</b> Increasing evidences suggest that carbon nanotubes (CNT) have adverse biological effects; however the exact mechanism of toxicity is poorly understood. More recently MWCNT-7 has been classified as Group 2B (possibly carcinogenic to humans) which necessitates study on the effect of CNT exposure in human. <b>Aim:</b> The present study was designed to assess the epigenetic alterations (primarily DNA methylation) induced by occupational exposure to CNT. <b>Method:</b> The study population included 8 operators, 16 R&D workers and 43 controls. The exposure to CNT in the workplace was measured during the study period. Subsequently, DNA samples were analyzed for global DNA methylation/de-methylation by LC-MS/MS. Levels of methylation of specific genes was measured by pyrosequencing. <b>Result:</b> In the production and R&D work space, CNT were aggregates were observed (200 nm–100 μm) with concentrations of 4.6–42.6 μg/m<sup>3</sup>. A preliminary analysis of global DNA methylation and hydroxymethylation using LC-MS/MS, adjusted for age, gender and smoking status did not reveal significant difference between the CNT exposed and control groups. Sequence specific global methylation analysis using LINE-1 did not reveal any significant difference. Sequence-specific DNA methylation in promoter region of ATM, SKI and HDAC4 genes did not reveal significant change. Significant hyper-methylation was observed for DNMT1 in the R&D workers. <b>Conclusion:</b> Since DNA methylation plays an important role in several biological processes through epigenetic silencing/regulation of genes, an aberrant methylation of DNMT1 might have a significant effect in various cellular processes. However, the results need to be validated in a larger cohort." @default.
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- W2553351021 date "2016-09-01" @default.
- W2553351021 modified "2023-10-10" @default.
- W2553351021 title "DNA methylation changes in workers occupational exposed to carbon nanotubes" @default.
- W2553351021 doi "https://doi.org/10.1183/13993003.congress-2016.pa4275" @default.
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