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• W2553360879 abstract "The salivary glands (SGs) of virus‐immune mice contain substantial numbers of tissue‐resident memory CD8 + T cells (T RM cells) that can provide immunity to local infections. Integrins regulate entry of activated T cells into nonlymphoid tissues but the molecules that mediate migration of virus‐specific CD8 + T cells to the SGs have not yet been defined. Here, we found that polyinosinic‐polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR‐transgenic CD8 + T RM cells in SGs in an α 4 β 1 integrin‐dependent manner. After infection with lymphocytic choriomeningitis virus, accumulation of P14 T RM cells in SGs and intestine but not in kidney was also α 4 integrin dependent. Blockade of α 4 β 7 by monoclonal antibodies (mAbs) inhibited lymphocytic choriomeningitis virus‐induced accumulation of P14 T RM cells in the intestine but not in SGs. In conclusion, our data reveal that α 4 β 1 integrin mediates CD8 + T RM accumulation in SGs and that poly(I:C) can be used to direct activated CD8 + T cells to this organ." @default.
• W2553360879 created "2016-11-30" @default.
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• W2553360879 date "2016-12-07" @default.
• W2553360879 modified "2023-10-18" @default.
• W2553360879 title "α₄β₁integrin promotes accumulation of tissue-resident memory CD8⁺T cells in salivary glands" @default.
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• W2553360879 doi "https://doi.org/10.1002/eji.201646722" @default.
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