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- W2553477572 abstract "Dopamine (DA) has been shown to exert a dopaminergic-receptor mediated bronchodilating potential in pre-constricted airways. However, its characteristic circulatory dose-dependent effects have not yet been evaluated on the airways. Further, bronchial effects of dobutamine (DX) as an alternative positive inotropic drug is unknown. Baseline respiratory mechanics were measured in 15 anaesthetized, ventilated rats by means of forced oscillations. The airway resistance (Raw) was approximately doubled with increasing doses of iv methacholine (MCh). In the presence of this elevated bronchial tone, iv infusion of DA or DX was started with a 10 and 5 µg/kg/min initial dose, respectively, followed by doubling the doses 3 times in every 10 min. Raw was also measured after stopping DA or DX while MCh was still administered. A 30-min MCh-free recovery period was then installed, and the protocol was repeated with the other inotropic drug in random sequence. Only the highest doses of DX and DA decreased Raw significantly (-23±7% and -21±6%, respectively, p Supported by OTKA grant K115253." @default.
- W2553477572 created "2016-11-30" @default.
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- W2553477572 date "2016-09-01" @default.
- W2553477572 modified "2023-10-16" @default.
- W2553477572 title "Dobutamine decreases an elevated airway tone similar to dopamine in rats" @default.
- W2553477572 doi "https://doi.org/10.1183/13993003.congress-2016.pa2268" @default.
- W2553477572 hasPublicationYear "2016" @default.
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