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- W2553480464 endingPage "449" @default.
- W2553480464 startingPage "441" @default.
- W2553480464 abstract "All pathogens must survive host immune attack and, amongst the survival strategies that have evolved, antigenic variation is a particularly widespread reaction to thwart adaptive immunity. Though the reactions that underlie antigenic variation are highly varied, recombination by gene conversion is a widespread approach to immune survival in bacterial and eukaryotic pathogens. In the African trypanosome, antigenic variation involves gene conversion-catalysed movement of a huge number of variant surface glycoprotein (VSG) genes into a few telomeric sites for VSG expression, amongst which only a single site is actively transcribed at one time. Genetic evidence indicates VSG gene conversion has co-opted the general genome maintenance reaction of homologous recombination, aligning the reaction strategy with targeted rearrangements found in many organisms. What is less clear is how gene conversion might be initiated within the locality of the VSG expression sites. Here, we discuss three emerging models for VSG switching initiation and ask how these compare with processes for adaptive genome change found in other organisms." @default.
- W2553480464 created "2016-11-30" @default.
- W2553480464 creator A5008036563 @default.
- W2553480464 creator A5043965341 @default.
- W2553480464 creator A5068074966 @default.
- W2553480464 date "2016-11-07" @default.
- W2553480464 modified "2023-10-18" @default.
- W2553480464 title "Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?" @default.
- W2553480464 cites W1415874556 @default.
- W2553480464 cites W1490937614 @default.
- W2553480464 cites W1515131566 @default.
- W2553480464 cites W1576894338 @default.
- W2553480464 cites W1724624251 @default.
- W2553480464 cites W1870349515 @default.
- W2553480464 cites W1887558133 @default.
- W2553480464 cites W1903520797 @default.
- W2553480464 cites W1904266719 @default.
- W2553480464 cites W1933226978 @default.
- W2553480464 cites W1939736088 @default.
- W2553480464 cites W1963937477 @default.
- W2553480464 cites W1964020301 @default.
- W2553480464 cites W1974854527 @default.
- W2553480464 cites W1982779105 @default.
- W2553480464 cites W1987395686 @default.
- W2553480464 cites W1994514609 @default.
- W2553480464 cites W1999142827 @default.
- W2553480464 cites W1999325162 @default.
- W2553480464 cites W1999617465 @default.
- W2553480464 cites W2002113064 @default.
- W2553480464 cites W2004438438 @default.
- W2553480464 cites W2010023443 @default.
- W2553480464 cites W2013351263 @default.
- W2553480464 cites W2014876899 @default.
- W2553480464 cites W2018041615 @default.
- W2553480464 cites W2019341601 @default.
- W2553480464 cites W2019738496 @default.
- W2553480464 cites W2020652742 @default.
- W2553480464 cites W2028930260 @default.
- W2553480464 cites W2031081673 @default.
- W2553480464 cites W2039272200 @default.
- W2553480464 cites W2041308771 @default.
- W2553480464 cites W2041583048 @default.
- W2553480464 cites W2043970825 @default.
- W2553480464 cites W2044138508 @default.
- W2553480464 cites W2052401924 @default.
- W2553480464 cites W2056298514 @default.
- W2553480464 cites W2058438089 @default.
- W2553480464 cites W2058519967 @default.
- W2553480464 cites W2062984650 @default.
- W2553480464 cites W2075479690 @default.
- W2553480464 cites W2079686164 @default.
- W2553480464 cites W2080301015 @default.
- W2553480464 cites W2090309533 @default.
- W2553480464 cites W2091258197 @default.
- W2553480464 cites W2103352899 @default.
- W2553480464 cites W2103796673 @default.
- W2553480464 cites W2105688902 @default.
- W2553480464 cites W2111565312 @default.
- W2553480464 cites W2112321215 @default.
- W2553480464 cites W2115094314 @default.
- W2553480464 cites W2116753034 @default.
- W2553480464 cites W2117815751 @default.
- W2553480464 cites W2123711644 @default.
- W2553480464 cites W2125295721 @default.
- W2553480464 cites W2125489655 @default.
- W2553480464 cites W2132096283 @default.
- W2553480464 cites W2132819134 @default.
- W2553480464 cites W2135677364 @default.
- W2553480464 cites W2137279138 @default.
- W2553480464 cites W2139920593 @default.
- W2553480464 cites W2141690385 @default.
- W2553480464 cites W2144254383 @default.
- W2553480464 cites W2144840612 @default.
- W2553480464 cites W2146893850 @default.
- W2553480464 cites W2150937967 @default.
- W2553480464 cites W2151336571 @default.
- W2553480464 cites W2152914165 @default.
- W2553480464 cites W2156920285 @default.
- W2553480464 cites W2163152147 @default.
- W2553480464 cites W2167448600 @default.
- W2553480464 cites W2170509903 @default.
- W2553480464 cites W2172044969 @default.
- W2553480464 cites W2200760358 @default.
- W2553480464 cites W2234143669 @default.
- W2553480464 cites W2253756154 @default.
- W2553480464 cites W2256990476 @default.
- W2553480464 cites W2304674135 @default.
- W2553480464 cites W2346473342 @default.
- W2553480464 cites W2402762370 @default.
- W2553480464 cites W2408088006 @default.
- W2553480464 cites W2411403337 @default.
- W2553480464 cites W2417917142 @default.
- W2553480464 cites W2502173429 @default.
- W2553480464 cites W4231531341 @default.
- W2553480464 cites W908721847 @default.
- W2553480464 cites W926901942 @default.
- W2553480464 doi "https://doi.org/10.1007/s00294-016-0662-7" @default.
- W2553480464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5422504" @default.