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- W2553513060 endingPage "83358" @default.
- W2553513060 startingPage "83342" @default.
- W2553513060 abstract "There is currently a paucity of preclinical models available to study the metastatic process in esophageal cancer. Here we report FLO-1, and its isogenic derivative FLO-1LM, as two spontaneously metastatic cell line models of human esophageal adenocarcinoma. We show that FLO-1 has undergone epithelial-mesenchymal transition and metastasizes following subcutaneous injection in mice. FLO-1LM, derived from a FLO-1 liver metastasis, has markedly enhanced proliferative, clonogenic, anti-apoptotic, invasive, immune-tolerant and metastatic potential. Genome-wide RNAseq profiling revealed a significant enrichment of metastasis-related pathways in FLO-1LM cells. Moreover, CDH1, which encodes the adhesion molecule E-cadherin, was the most significantly downregulated gene in FLO-1LM compared to FLO-1. Consistent with this, repression of E-cadherin expression in FLO-1 cells resulted in increased metastatic activity. Importantly, reduced E-cadherin expression is commonly reported in esophageal adenocarcinoma and independently predicts poor patient survival. Collectively, these findings highlight the biological importance of E-cadherin activity in the pathogenesis of metastatic esophageal adenocarcinoma and validate the utility of FLO-1 parental and FLO-1LM cells as preclinical models of metastasis in this disease." @default.
- W2553513060 created "2016-11-30" @default.
- W2553513060 creator A5006400876 @default.
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- W2553513060 creator A5082639989 @default.
- W2553513060 date "2016-11-16" @default.
- W2553513060 modified "2023-10-16" @default.
- W2553513060 title "Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis" @default.
- W2553513060 cites W1185133553 @default.
- W2553513060 cites W1532132165 @default.
- W2553513060 cites W1577897965 @default.
- W2553513060 cites W1672531970 @default.
- W2553513060 cites W1705649792 @default.
- W2553513060 cites W1710102054 @default.
- W2553513060 cites W1760284500 @default.
- W2553513060 cites W178567571 @default.
- W2553513060 cites W1921634367 @default.
- W2553513060 cites W1925882120 @default.
- W2553513060 cites W1968542304 @default.
- W2553513060 cites W1971278891 @default.
- W2553513060 cites W1971781695 @default.
- W2553513060 cites W1974048869 @default.
- W2553513060 cites W1976198146 @default.
- W2553513060 cites W1980546153 @default.
- W2553513060 cites W1980873645 @default.
- W2553513060 cites W1984668606 @default.
- W2553513060 cites W1984724231 @default.
- W2553513060 cites W1992499848 @default.
- W2553513060 cites W1993361862 @default.
- W2553513060 cites W1993651604 @default.
- W2553513060 cites W1995041998 @default.
- W2553513060 cites W1996291678 @default.
- W2553513060 cites W1998419385 @default.
- W2553513060 cites W2001146267 @default.
- W2553513060 cites W2010014640 @default.
- W2553513060 cites W2011290774 @default.
- W2553513060 cites W2015997189 @default.
- W2553513060 cites W2016124362 @default.
- W2553513060 cites W2016291097 @default.
- W2553513060 cites W2021809205 @default.
- W2553513060 cites W2024123171 @default.
- W2553513060 cites W2037992314 @default.
- W2553513060 cites W2040330822 @default.
- W2553513060 cites W2041560748 @default.
- W2553513060 cites W2043966181 @default.
- W2553513060 cites W2048896744 @default.
- W2553513060 cites W2052012115 @default.
- W2553513060 cites W2056782519 @default.
- W2553513060 cites W2058743721 @default.
- W2553513060 cites W2060230325 @default.
- W2553513060 cites W2060444505 @default.
- W2553513060 cites W2061082942 @default.
- W2553513060 cites W2062641317 @default.
- W2553513060 cites W2064535941 @default.
- W2553513060 cites W2066067183 @default.
- W2553513060 cites W2069333925 @default.
- W2553513060 cites W2072301658 @default.
- W2553513060 cites W2073026455 @default.
- W2553513060 cites W2076025174 @default.
- W2553513060 cites W2078131794 @default.
- W2553513060 cites W2080520337 @default.
- W2553513060 cites W2084201622 @default.
- W2553513060 cites W2085364726 @default.
- W2553513060 cites W2086492013 @default.
- W2553513060 cites W2086500796 @default.
- W2553513060 cites W2090800413 @default.
- W2553513060 cites W2095608027 @default.
- W2553513060 cites W2101013582 @default.
- W2553513060 cites W2106856635 @default.
- W2553513060 cites W2114906733 @default.
- W2553513060 cites W2118566883 @default.
- W2553513060 cites W2119594675 @default.
- W2553513060 cites W2120608850 @default.
- W2553513060 cites W2121901052 @default.
- W2553513060 cites W2125393630 @default.
- W2553513060 cites W2128482295 @default.
- W2553513060 cites W2136130863 @default.
- W2553513060 cites W2137906256 @default.
- W2553513060 cites W2138703169 @default.
- W2553513060 cites W2145254159 @default.
- W2553513060 cites W2146509619 @default.
- W2553513060 cites W2147977885 @default.
- W2553513060 cites W2150789050 @default.
- W2553513060 cites W2154589460 @default.
- W2553513060 cites W2161048060 @default.
- W2553513060 cites W2164823210 @default.
- W2553513060 cites W2165343015 @default.
- W2553513060 cites W2167963632 @default.
- W2553513060 cites W2168740359 @default.
- W2553513060 cites W2170056461 @default.