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- W2553514617 abstract "Hypoxia enhances immortality and metastatic properties of solid tumors. Deregulation of histone acetylation has been associated with several metastatic cancers but its effect on hypoxic responses of cancer cells is not known. This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl2), a hypoxia-mimetic chemical, or 1% O2. Here, we show that CTK7A-induced hydrogen peroxide (H2O2) generation in CoCl2-exposed and invasive gastric cancer cells (GCCs) leads to p38 MAPK-mediated Noxa expression and thereafter, mitochondrial apoptotic events. Noxa induction in normal immortalized gastric epithelial cells after CTK7A and hypoxia-exposure is remarkably less in comparison to similarly-treated GCCs. Moreover, hypoxia-exposed GCCs, which have acquired invasive properties, become apoptotic after CTK7A treatment to a significantly higher extent than normoxic cells. Thus, we show the potential of CTK7A in sensitizing hypoxic and metastatic GCCs to apoptosis induction." @default.
- W2553514617 created "2016-11-30" @default.
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- W2553514617 date "2017-01-01" @default.
- W2553514617 modified "2023-10-17" @default.
- W2553514617 title "Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness" @default.
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- W2553514617 cites W1968187585 @default.
- W2553514617 cites W1969950487 @default.
- W2553514617 cites W1976845934 @default.
- W2553514617 cites W1979784399 @default.
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- W2553514617 cites W1998700867 @default.
- W2553514617 cites W2001409228 @default.
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- W2553514617 doi "https://doi.org/10.1016/j.biocel.2016.11.014" @default.
- W2553514617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5718055" @default.
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