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- W2553514881 abstract "Triple-negative breast cancer (TNBC) is a heterogeneous group of tumours characterised by lack of expression of oestrogen-, progesterone- and human epidermal growth factor receptors. TNBC, which represents approximately 15% of all mammary tumours, has a poor prognosis because of an aggressive behaviour and the lack of specific treatment. Accordingly, TNBC has become a major focus of research into breast cancer and is now classified into several molecular subtypes, each with a different prognosis. Pathological angiogenesis occurs at a late stage in the proliferation of TNBC and is associated with invasion and metastasis; there is an association with metabolic syndrome. Semaphorins are a versatile family of proteins with multiple roles in angiogenesis, tumour growth and metastasis and may represent a clinically useful focus for therapeutic targeting in this type of breast cancer. Another important field of investigation into the control of pathological angiogenesis is related to the expression of noncoding RNA (ncRNA) – these molecules can be considered as a therapeutic target or as a biomarker. Several molecular agents for intervening in the activity of different signalling pathways are being explored in TNBC, but none has so far proved effective in clinical trials and the disease continues to pose a defining challenge for clinical management as well as innovative cancer research." @default.
- W2553514881 created "2016-11-30" @default.
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- W2553514881 date "2016-01-01" @default.
- W2553514881 modified "2023-09-25" @default.
- W2553514881 title "Novel insight into triple-negative breast cancers, the emerging role of angiogenesis, and antiangiogenic therapy" @default.
- W2553514881 cites W1006064918 @default.
- W2553514881 cites W1238924984 @default.
- W2553514881 cites W1509291382 @default.
- W2553514881 cites W1517573550 @default.
- W2553514881 cites W1600702886 @default.
- W2553514881 cites W1656241491 @default.
- W2553514881 cites W1734411634 @default.
- W2553514881 cites W1754869596 @default.
- W2553514881 cites W1774029313 @default.
- W2553514881 cites W1921704765 @default.
- W2553514881 cites W1932374941 @default.
- W2553514881 cites W1934292000 @default.
- W2553514881 cites W1964814161 @default.
- W2553514881 cites W1966808661 @default.
- W2553514881 cites W1967758113 @default.
- W2553514881 cites W1968020290 @default.
- W2553514881 cites W1969461868 @default.
- W2553514881 cites W1971237954 @default.
- W2553514881 cites W1976552085 @default.
- W2553514881 cites W1979634131 @default.
- W2553514881 cites W1979773713 @default.
- W2553514881 cites W1981966610 @default.
- W2553514881 cites W1984065470 @default.
- W2553514881 cites W1985403743 @default.
- W2553514881 cites W1989588894 @default.
- W2553514881 cites W1989938935 @default.
- W2553514881 cites W1991209600 @default.
- W2553514881 cites W1992287299 @default.
- W2553514881 cites W1992651360 @default.
- W2553514881 cites W1992721855 @default.
- W2553514881 cites W1992929567 @default.
- W2553514881 cites W1993188287 @default.
- W2553514881 cites W1996188527 @default.
- W2553514881 cites W1996331246 @default.
- W2553514881 cites W1997961380 @default.
- W2553514881 cites W1998710183 @default.
- W2553514881 cites W2003069734 @default.
- W2553514881 cites W2003093717 @default.
- W2553514881 cites W2003879042 @default.
- W2553514881 cites W2007997332 @default.
- W2553514881 cites W2019812445 @default.
- W2553514881 cites W2020189115 @default.
- W2553514881 cites W2024403356 @default.
- W2553514881 cites W2027441950 @default.
- W2553514881 cites W2028356733 @default.
- W2553514881 cites W2030739512 @default.
- W2553514881 cites W2032012444 @default.
- W2553514881 cites W2038918331 @default.
- W2553514881 cites W2040558370 @default.
- W2553514881 cites W2041432445 @default.
- W2553514881 cites W2041497771 @default.
- W2553514881 cites W2042978168 @default.
- W2553514881 cites W2044151404 @default.
- W2553514881 cites W2047207774 @default.
- W2553514881 cites W2047470479 @default.
- W2553514881 cites W2048597171 @default.
- W2553514881 cites W2051350518 @default.
- W2553514881 cites W2056928766 @default.
- W2553514881 cites W2058013893 @default.
- W2553514881 cites W2058073773 @default.
- W2553514881 cites W2058258976 @default.
- W2553514881 cites W2064241564 @default.
- W2553514881 cites W2064741113 @default.
- W2553514881 cites W2067832306 @default.
- W2553514881 cites W2072467653 @default.
- W2553514881 cites W2077065310 @default.
- W2553514881 cites W2079991309 @default.
- W2553514881 cites W2080204015 @default.
- W2553514881 cites W2081174442 @default.
- W2553514881 cites W2082749988 @default.
- W2553514881 cites W2085745363 @default.
- W2553514881 cites W2086977605 @default.
- W2553514881 cites W2087990211 @default.
- W2553514881 cites W2091733153 @default.
- W2553514881 cites W2097255042 @default.
- W2553514881 cites W2098276344 @default.
- W2553514881 cites W2100160619 @default.
- W2553514881 cites W2101017424 @default.
- W2553514881 cites W2104056913 @default.
- W2553514881 cites W2104354342 @default.
- W2553514881 cites W2106024892 @default.
- W2553514881 cites W2106359723 @default.
- W2553514881 cites W2107888799 @default.
- W2553514881 cites W2111818745 @default.
- W2553514881 cites W2112581947 @default.