FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553516672> ?p ?o ?g. }

• W2553516672 endingPage "209" @default.
• W2553516672 startingPage "195" @default.
• W2553516672 abstract "Background and Purpose Fulminant hepatic failure (FHF) is a fatal clinical syndrome that results in excessive inflammation and hepatocyte death. Mitochondrial dysfunction is considered to be a possible mechanism of FHF. Afzelin, a flavonol glycoside found in Houttuynia cordata Thunberg, has anti‐inflammatory and antioxidant properties. The present study elucidated the cytoprotective mechanisms of afzelin against D‐galactosamine (GalN)/LPS induced FHF, particularly focusing on mitochondrial quality control and dynamics. Experimental Approach Mice were administered afzelin i.p. 1 h before receiving GalN (800 mg·kg −1 )/LPS (40 μg·kg −1 ), and they were then killed 5 h after GalN/LPS treatment. Key Results Afzelin improved the survival rate and reduced the serum levels of alanine aminotransferase and pro‐inflammatory cytokines in GalN/LPS‐treated mice. Afzelin attenuated the mitochondrial damage, as indicated by diminished mitochondrial swelling and mitochondrial glutamate dehydrogenase activity in GalN/LPS‐treated mice. Afzelin enhanced mitochondrial biogenesis, as indicated by increased levels of PPAR‐γ coactivator 1α, nuclear respiratory factor 1 and mitochondrial transcription factor A. Afzelin also decreased the level of mitophagy‐related proteins, parkin and PTEN‐induced putative kinase 1. Furthermore, while GalN/LPS significantly increased the level of fission‐related protein, dynamin‐related protein 1, and decreased the level of fusion‐related protein, mitofusin 2; these effects were attenuated by afzelin. Conclusions and Implications Our findings demonstrated that afzelin protects against GalN/LPS‐induced liver injury by enhancing mitochondrial biogenesis, suppressing excessive mitophagy and balancing mitochondrial dynamics." @default.
• W2553516672 created "2016-11-30" @default.
• W2553516672 creator A5004405152 @default.
• W2553516672 creator A5032551438 @default.
• W2553516672 creator A5048971680 @default.
• W2553516672 creator A5066144953 @default.
• W2553516672 creator A5081185798 @default.
• W2553516672 creator A5088988274 @default.
• W2553516672 date "2016-12-15" @default.
• W2553516672 modified "2023-10-05" @default.
• W2553516672 title "Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics" @default.
• W2553516672 cites W1261741285 @default.
• W2553516672 cites W1586820518 @default.
• W2553516672 cites W1593555249 @default.
• W2553516672 cites W1596457615 @default.
• W2553516672 cites W1771064161 @default.
• W2553516672 cites W1888470382 @default.
• W2553516672 cites W1959956691 @default.
• W2553516672 cites W1985884583 @default.
• W2553516672 cites W1991222876 @default.
• W2553516672 cites W1992053460 @default.
• W2553516672 cites W1992262912 @default.
• W2553516672 cites W2006589528 @default.
• W2553516672 cites W2014780202 @default.
• W2553516672 cites W2022997027 @default.
• W2553516672 cites W2024402543 @default.
• W2553516672 cites W2025602337 @default.
• W2553516672 cites W2036275511 @default.
• W2553516672 cites W2044929466 @default.
• W2553516672 cites W2054303797 @default.
• W2553516672 cites W2064341136 @default.
• W2553516672 cites W2064734428 @default.
• W2553516672 cites W2064770895 @default.
• W2553516672 cites W2068836067 @default.
• W2553516672 cites W2070328798 @default.
• W2553516672 cites W2074769050 @default.
• W2553516672 cites W2079336314 @default.
• W2553516672 cites W2080295051 @default.
• W2553516672 cites W2098864641 @default.
• W2553516672 cites W2099837354 @default.
• W2553516672 cites W2104954806 @default.
• W2553516672 cites W2109882045 @default.
• W2553516672 cites W2110795504 @default.
• W2553516672 cites W2113515610 @default.
• W2553516672 cites W2114638332 @default.
• W2553516672 cites W2116562304 @default.
• W2553516672 cites W2121198137 @default.
• W2553516672 cites W2121580924 @default.
• W2553516672 cites W2123476161 @default.
• W2553516672 cites W2124140045 @default.
• W2553516672 cites W2125302529 @default.
• W2553516672 cites W2126712128 @default.
• W2553516672 cites W2138310507 @default.
• W2553516672 cites W2151495088 @default.
• W2553516672 cites W2152594080 @default.
• W2553516672 cites W2153850374 @default.
• W2553516672 cites W2161291398 @default.
• W2553516672 cites W2170228248 @default.
• W2553516672 cites W2192646420 @default.
• W2553516672 cites W2194756172 @default.
• W2553516672 cites W2196064518 @default.
• W2553516672 cites W2287400727 @default.
• W2553516672 cites W2322120913 @default.
• W2553516672 cites W2414702137 @default.
• W2553516672 cites W601488828 @default.
• W2553516672 doi "https://doi.org/10.1111/bph.13669" @default.
• W2553516672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5192940" @default.
• W2553516672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27861739" @default.
• W2553516672 hasPublicationYear "2016" @default.
• W2553516672 type Work @default.
• W2553516672 sameAs 2553516672 @default.
• W2553516672 citedByCount "28" @default.
• W2553516672 countsByYear W25535166722018 @default.
• W2553516672 countsByYear W25535166722019 @default.
• W2553516672 countsByYear W25535166722020 @default.
• W2553516672 countsByYear W25535166722021 @default.
• W2553516672 countsByYear W25535166722022 @default.
• W2553516672 countsByYear W25535166722023 @default.
• W2553516672 crossrefType "journal-article" @default.
• W2553516672 hasAuthorship W2553516672A5004405152 @default.
• W2553516672 hasAuthorship W2553516672A5032551438 @default.
• W2553516672 hasAuthorship W2553516672A5048971680 @default.
• W2553516672 hasAuthorship W2553516672A5066144953 @default.
• W2553516672 hasAuthorship W2553516672A5081185798 @default.
• W2553516672 hasAuthorship W2553516672A5088988274 @default.
• W2553516672 hasBestOaLocation W25535166721 @default.
• W2553516672 hasConcept C126322002 @default.
• W2553516672 hasConcept C181199279 @default.
• W2553516672 hasConcept C185592680 @default.
• W2553516672 hasConcept C2776514860 @default.
• W2553516672 hasConcept C2777229759 @default.
• W2553516672 hasConcept C28859421 @default.
• W2553516672 hasConcept C538909803 @default.
• W2553516672 hasConcept C55493867 @default.
• W2553516672 hasConcept C71924100 @default.
• W2553516672 hasConcept C86803240 @default.
• W2553516672 hasConcept C98274493 @default.
• W2553516672 hasConceptScore W2553516672C126322002 @default.

• next