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- W2553535210 abstract "INTRODUCTION: Long-term medications in asthma patients are needed to control symptoms. But, asthma control is considered to be suboptimal regardless of the availability of conventional treatments. Traditionally, Nigella sativa (NS), known as black seed, is thought to be effective in asthma. OBJECTIVE: To investigate the benefits of NS supplementation on clinical and inflammatory parameters of asthma. METHODS: NS oil (Marnys ® ) was used as “add-on” treatment option in a randomised, double-blind, placebo-controlled, phase II trial. The primary endpoint was Asthma Control Test (ACT) score. The secondary endpoints were predicted FEV1%, blood eosinophils, total IgE, and multiple inflammatory mediators. Independent t and Mann–Whitney U statistical tests were used. The trial was registered at clinicaltrials.gov; NCT02407262. RESULTS: Eighty patients enrolled between Jun 1 and Dec 30, 2015, with forty patients each randomly assigned to treatment (NS) and placebo groups. At the end of four weeks treatment, ten patients withdrawn from each group. Patients in treatment group (n=30) had a significant improvement in mean ACT 2 score over placebo (n=30) (476(SD=99) vs 401(SD=146) p=0.024, respectively). Blood eosinophils reduced by median –0.055 (-1.770–0.162) in treatment vs -0.015 (-0.330–0.340) in placebo p=0.008. NS positively improved predicted FEV1% by median 4% (-6–20) in treatment vs 1% (-14–20) in placebo p=0.170. But, IgE levels did not improve. CONCLUSION: NS appeared to be improving asthma symptoms, blood eosinophilia and lung function. Future studies should follow patients for a longer period and validate outcomes using different approaches." @default.
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- W2553535210 date "2016-09-01" @default.
- W2553535210 modified "2023-09-25" @default.
- W2553535210 title "LATE-BREAKING ABSTRACT: The benefits ofNigella sativaoil supplementation on asthma inflammation: A randomised, double-blind, placebo-controlled, phase II trial" @default.
- W2553535210 doi "https://doi.org/10.1183/13993003.congress-2016.oa4830" @default.
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