Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553537563> ?p ?o ?g. }
- W2553537563 endingPage "96" @default.
- W2553537563 startingPage "81" @default.
- W2553537563 abstract "Host mucin is the main constituent of the mucus layer that covers the gut epithelium of the host, and an important source of glycans for the bacteria colonising the intestine. Akkermansia muciniphila is a mucin-degrading bacterium, abundant in the human gut, that is able to produce acetate and propionate during this degradation process. A. muciniphila has been correlated with human health in previous studies, but a mechanistic explanation is lacking. In this study, the main site of colonisation was characterised alongside additional conditions, such as differences in colon pH, prebiotic supplementation and variable mucin supply. To overcome the limitations of in vivo studies concerning variations in mucin availability and difficult access to proximal regions of the colon, a dynamic in vitro gut model (SHIME) was used. In this model, A. muciniphila was found to colonise the distal colon compartment more abundantly than the proximal colon ((±8 log copies/ml compared to ±4 log copies/ml) and the preference for the distal compartment was found to be pH-dependent. The addition of mucin caused a specific increase of A. muciniphila (±4.5 log increase over two days), far exceeding the response of other bacteria present, together with an increase in propionate. These findings suggest that colonisation and mucin degradation by A. muciniphila is dependent on pH and the concentration of mucin. Our results revealed the preference of A. muciniphila for the distal colon environment due to its higher pH and uncovered the quick and stable response of A. muciniphila to mucin supplementation." @default.
- W2553537563 created "2016-11-30" @default.
- W2553537563 creator A5007310511 @default.
- W2553537563 creator A5008284141 @default.
- W2553537563 creator A5015518153 @default.
- W2553537563 creator A5017793189 @default.
- W2553537563 creator A5027219705 @default.
- W2553537563 creator A5032471444 @default.
- W2553537563 creator A5034152101 @default.
- W2553537563 creator A5057739595 @default.
- W2553537563 creator A5058807580 @default.
- W2553537563 creator A5069973187 @default.
- W2553537563 creator A5076402284 @default.
- W2553537563 creator A5089634969 @default.
- W2553537563 date "2017-02-07" @default.
- W2553537563 modified "2023-10-17" @default.
- W2553537563 title "<i>In vitro</i> colonisation of the distal colon by <i>Akkermansia muciniphila</i> is largely mucin and pH dependent" @default.
- W2553537563 cites W1533313469 @default.
- W2553537563 cites W1835824024 @default.
- W2553537563 cites W1885011557 @default.
- W2553537563 cites W1903714462 @default.
- W2553537563 cites W1964186648 @default.
- W2553537563 cites W1966921473 @default.
- W2553537563 cites W1978195655 @default.
- W2553537563 cites W1985609109 @default.
- W2553537563 cites W1988239239 @default.
- W2553537563 cites W1989802059 @default.
- W2553537563 cites W2001307702 @default.
- W2553537563 cites W2004158639 @default.
- W2553537563 cites W2013837504 @default.
- W2553537563 cites W2018069658 @default.
- W2553537563 cites W2021251015 @default.
- W2553537563 cites W2022837689 @default.
- W2553537563 cites W2024638703 @default.
- W2553537563 cites W2027352386 @default.
- W2553537563 cites W2027788816 @default.
- W2553537563 cites W2030364983 @default.
- W2553537563 cites W2032112360 @default.
- W2553537563 cites W2034082915 @default.
- W2553537563 cites W2037111559 @default.
- W2553537563 cites W2039167760 @default.
- W2553537563 cites W2045119680 @default.
- W2553537563 cites W2045249249 @default.
- W2553537563 cites W2049771483 @default.
- W2553537563 cites W2051312690 @default.
- W2553537563 cites W2054112179 @default.
- W2553537563 cites W2056279562 @default.
- W2553537563 cites W2059004028 @default.
- W2553537563 cites W2068368322 @default.
- W2553537563 cites W2071841602 @default.
- W2553537563 cites W2075753061 @default.
- W2553537563 cites W2076474430 @default.
- W2553537563 cites W2081043824 @default.
- W2553537563 cites W2082407725 @default.
- W2553537563 cites W2082808164 @default.
- W2553537563 cites W2083278327 @default.
- W2553537563 cites W2084512022 @default.
- W2553537563 cites W2084793748 @default.
- W2553537563 cites W2088192427 @default.
- W2553537563 cites W2088556529 @default.
- W2553537563 cites W2091922579 @default.
- W2553537563 cites W2092466285 @default.
- W2553537563 cites W2096736123 @default.
- W2553537563 cites W2098982006 @default.
- W2553537563 cites W2099456560 @default.
- W2553537563 cites W2100692896 @default.
- W2553537563 cites W2106528813 @default.
- W2553537563 cites W2111317067 @default.
- W2553537563 cites W2125678015 @default.
- W2553537563 cites W2125970192 @default.
- W2553537563 cites W2126146585 @default.
- W2553537563 cites W2128743925 @default.
- W2553537563 cites W2133309481 @default.
- W2553537563 cites W2134241692 @default.
- W2553537563 cites W2135086766 @default.
- W2553537563 cites W2138950086 @default.
- W2553537563 cites W2139334262 @default.
- W2553537563 cites W2146375732 @default.
- W2553537563 cites W2146565796 @default.
- W2553537563 cites W2147790901 @default.
- W2553537563 cites W2151159165 @default.
- W2553537563 cites W2152885278 @default.
- W2553537563 cites W2153075279 @default.
- W2553537563 cites W2156962544 @default.
- W2553537563 cites W2159915913 @default.
- W2553537563 cites W2160427027 @default.
- W2553537563 cites W2160883824 @default.
- W2553537563 cites W2164116345 @default.
- W2553537563 cites W2168350061 @default.
- W2553537563 cites W2169351489 @default.
- W2553537563 cites W2188930066 @default.
- W2553537563 cites W2206854629 @default.
- W2553537563 cites W2237053013 @default.
- W2553537563 doi "https://doi.org/10.3920/bm2016.0013" @default.
- W2553537563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27824274" @default.
- W2553537563 hasPublicationYear "2017" @default.
- W2553537563 type Work @default.
- W2553537563 sameAs 2553537563 @default.