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- W2553539 abstract "Background: Alcohol abuse is a risk factor for bone damage and fracture-related complications. Through precise β-catenin signaling, canonical Wnt signaling plays a key role in fracture repair by promoting the differentiation of new bone and cartilage cells. In this study, we examined the effects of alcohol on the Wnt pathway in injured bone using a murine model of alcohol-induced impaired fracture healing. Methods: Male C57Bl/6 or TCF-transgenic mice were administered 3 consecutive daily intraperitoneal doses of alcohol or saline. For biomechanical studies, mice were given 3 consecutive doses, left undisturbed for 4 days, then given an additional 3 consecutive daily injections for a total of 6 intraperitoneal doses. One hour following the final injection, mice were subjected to a stabilized, mid-shaft tibial fracture. Injured and contralateral tibias were harvested at 6, 9, or 14 days post-fracture for analysis of fracture callus size, biomechanical strength, tissue composition, and activation of the Wnt/βcatenin pathway. Results: Acute binge alcohol treatment was associated with a significant decrease in fracture callus volume, diameter, and biomechanical strength at day 14 post-fracture. Histology revealed an alcohol-related reduction in cartilage and bone formation at the" @default.
- W2553539 created "2016-06-24" @default.
- W2553539 creator A5023866306 @default.
- W2553539 date "2012-01-01" @default.
- W2553539 modified "2023-09-26" @default.
- W2553539 title "Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair" @default.
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