Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553556248> ?p ?o ?g. }
- W2553556248 endingPage "1831" @default.
- W2553556248 startingPage "1819" @default.
- W2553556248 abstract "Hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which might contribute to cognitive deficits observed in Alzheimer’s disease (AD). Although pro-opiomelanocortin (POMC)-derived neuropeptides and melanocortin 4 receptor (MC4R) are implicated in hippocampus-dependent synaptic plasticity, how the POMC/MC4R system functions in the hippocampus and its role in synaptic dysfunction in AD are largely unknown. Here, we mapped a functional POMC circuit in the mouse hippocampus, wherein POMC neurons in the cornu ammonis 3 (CA3) activate MC4R in the CA1. Suppression of hippocampal MC4R activity in the APP/PS1 transgenic mouse model of AD exacerbates long-term potentiation impairment, which is alleviated by the replenishment of hippocampal POMC/MC4R activity or activation of hippocampal MC4R-coupled Gs signaling. Importantly, MC4R activation rescues amyloid-β-induced synaptic dysfunction via a Gs/cyclic AMP (cAMP)/PKA/cAMP-response element binding protein (CREB)-dependent mechanism. Hence, disruption of this hippocampal POMC/MC4R circuit might contribute to synaptic dysfunction observed in AD, revealing a potential therapeutic target for the disease." @default.
- W2553556248 created "2016-11-30" @default.
- W2553556248 creator A5018607540 @default.
- W2553556248 creator A5038007210 @default.
- W2553556248 creator A5060875971 @default.
- W2553556248 creator A5061248522 @default.
- W2553556248 creator A5070364069 @default.
- W2553556248 creator A5075938969 @default.
- W2553556248 date "2016-11-01" @default.
- W2553556248 modified "2023-10-16" @default.
- W2553556248 title "Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model" @default.
- W2553556248 cites W1516631422 @default.
- W2553556248 cites W1553011341 @default.
- W2553556248 cites W1965137281 @default.
- W2553556248 cites W1970200165 @default.
- W2553556248 cites W1981455527 @default.
- W2553556248 cites W1987518908 @default.
- W2553556248 cites W1988011540 @default.
- W2553556248 cites W1992149698 @default.
- W2553556248 cites W1994143270 @default.
- W2553556248 cites W1996692205 @default.
- W2553556248 cites W2003738638 @default.
- W2553556248 cites W2017257616 @default.
- W2553556248 cites W2023986336 @default.
- W2553556248 cites W2027906603 @default.
- W2553556248 cites W2030575711 @default.
- W2553556248 cites W2032363478 @default.
- W2553556248 cites W2038440451 @default.
- W2553556248 cites W2038513471 @default.
- W2553556248 cites W2040784233 @default.
- W2553556248 cites W2042396829 @default.
- W2553556248 cites W2043785073 @default.
- W2553556248 cites W2046033692 @default.
- W2553556248 cites W2047239836 @default.
- W2553556248 cites W2048236085 @default.
- W2553556248 cites W2050066016 @default.
- W2553556248 cites W2069381818 @default.
- W2553556248 cites W2073769248 @default.
- W2553556248 cites W2086789852 @default.
- W2553556248 cites W2087465947 @default.
- W2553556248 cites W2092284040 @default.
- W2553556248 cites W2093316793 @default.
- W2553556248 cites W2107165322 @default.
- W2553556248 cites W2121379737 @default.
- W2553556248 cites W2131180711 @default.
- W2553556248 cites W2136901555 @default.
- W2553556248 cites W2141060229 @default.
- W2553556248 cites W2156118860 @default.
- W2553556248 cites W2164894105 @default.
- W2553556248 cites W2167731576 @default.
- W2553556248 cites W2168334242 @default.
- W2553556248 cites W2168489336 @default.
- W2553556248 cites W2168569995 @default.
- W2553556248 cites W2170532212 @default.
- W2553556248 doi "https://doi.org/10.1016/j.celrep.2016.10.043" @default.
- W2553556248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27829153" @default.
- W2553556248 hasPublicationYear "2016" @default.
- W2553556248 type Work @default.
- W2553556248 sameAs 2553556248 @default.
- W2553556248 citedByCount "42" @default.
- W2553556248 countsByYear W25535562482017 @default.
- W2553556248 countsByYear W25535562482018 @default.
- W2553556248 countsByYear W25535562482019 @default.
- W2553556248 countsByYear W25535562482020 @default.
- W2553556248 countsByYear W25535562482021 @default.
- W2553556248 countsByYear W25535562482022 @default.
- W2553556248 countsByYear W25535562482023 @default.
- W2553556248 crossrefType "journal-article" @default.
- W2553556248 hasAuthorship W2553556248A5018607540 @default.
- W2553556248 hasAuthorship W2553556248A5038007210 @default.
- W2553556248 hasAuthorship W2553556248A5060875971 @default.
- W2553556248 hasAuthorship W2553556248A5061248522 @default.
- W2553556248 hasAuthorship W2553556248A5070364069 @default.
- W2553556248 hasAuthorship W2553556248A5075938969 @default.
- W2553556248 hasBestOaLocation W25535562481 @default.
- W2553556248 hasConcept C104317684 @default.
- W2553556248 hasConcept C148762608 @default.
- W2553556248 hasConcept C1629964 @default.
- W2553556248 hasConcept C169760540 @default.
- W2553556248 hasConcept C170493617 @default.
- W2553556248 hasConcept C25274449 @default.
- W2553556248 hasConcept C2781161787 @default.
- W2553556248 hasConcept C55493867 @default.
- W2553556248 hasConcept C86339819 @default.
- W2553556248 hasConcept C86803240 @default.
- W2553556248 hasConcept C98229152 @default.
- W2553556248 hasConceptScore W2553556248C104317684 @default.
- W2553556248 hasConceptScore W2553556248C148762608 @default.
- W2553556248 hasConceptScore W2553556248C1629964 @default.
- W2553556248 hasConceptScore W2553556248C169760540 @default.
- W2553556248 hasConceptScore W2553556248C170493617 @default.
- W2553556248 hasConceptScore W2553556248C25274449 @default.
- W2553556248 hasConceptScore W2553556248C2781161787 @default.
- W2553556248 hasConceptScore W2553556248C55493867 @default.
- W2553556248 hasConceptScore W2553556248C86339819 @default.
- W2553556248 hasConceptScore W2553556248C86803240 @default.
- W2553556248 hasConceptScore W2553556248C98229152 @default.
- W2553556248 hasFunder F4320335055 @default.