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- W2553559042 endingPage "1618" @default.
- W2553559042 startingPage "1607" @default.
- W2553559042 abstract "Oncogenesis is a pathologic process driven by genomic aberrations, including changes in nucleotide sequences. The majority of these mutational events fall into two broad categories: inactivation of tumor suppressor genes (hypomorph, antimorph or amorph) or activation of oncogenes (hypermorph). The recent surge in genome sequence data and functional genomics research has ushered in the discovery of aberrations in a third category: gain-of-novel-function mutation (neomorph). These neomorphic mutations, which can be found in both tumor suppressor genes and oncogenes, produce proteins with entirely different functions from their respective wild-type (WT) proteins and the other morphs. The unanticipated phenotypic outcomes elicited by neomorphic mutations imply that tumors with the neomorphic mutations may not respond to therapies designed to target the WT protein. Therefore, understanding the functional activities of each genomic aberration to be targeted is crucial in devising effective treatment strategies that will benefit specific cancer patients." @default.
- W2553559042 created "2016-11-30" @default.
- W2553559042 creator A5010677692 @default.
- W2553559042 creator A5024534066 @default.
- W2553559042 creator A5035665490 @default.
- W2553559042 creator A5044665651 @default.
- W2553559042 creator A5084233435 @default.
- W2553559042 date "2016-11-14" @default.
- W2553559042 modified "2023-10-02" @default.
- W2553559042 title "Neomorphic mutations create therapeutic challenges in cancer" @default.
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