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- W2553568946 abstract "Stem cells have the remarkable ability to undergo proliferative symmetric divisions and self-renewing asymmetric divisions. Balancing of the two modes of division sustains tissue morphogenesis and homeostasis. Asymmetric divisions of Drosophila neuroblasts (NBs) and sensory organ precursor (SOP) cells served as prototypes to learn what we consider now principles of asymmetric mitoses. They also provide initial evidence supporting the notion that aberrant symmetric divisions of stem cells could correlate with malignancy. However, transferring the molecular knowledge of circuits underlying asymmetry from flies to mammals has proven more challenging than expected. Several experimental approaches have been used to define asymmetry in mammalian systems, based on daughter cell fate, unequal partitioning of determinants and niche contacts, or proliferative potential. In this review, we aim to provide a critical evaluation of the assays used to establish the stem cell mode of division, with a particular focus on the mammary gland system. In this context, we will discuss the genetic alterations that impinge on the modality of stem cell division and their role in breast cancer development." @default.
- W2553568946 created "2016-11-30" @default.
- W2553568946 creator A5046311260 @default.
- W2553568946 creator A5052146342 @default.
- W2553568946 creator A5057101865 @default.
- W2553568946 creator A5075095822 @default.
- W2553568946 creator A5091125903 @default.
- W2553568946 date "2016-11-21" @default.
- W2553568946 modified "2023-10-12" @default.
- W2553568946 title "Molecular mechanisms of asymmetric divisions in mammary stem cells" @default.
- W2553568946 cites W1492126200 @default.
- W2553568946 cites W1518709728 @default.
- W2553568946 cites W1558425393 @default.
- W2553568946 cites W1623601970 @default.
- W2553568946 cites W1814546794 @default.
- W2553568946 cites W1874198492 @default.
- W2553568946 cites W1919877068 @default.
- W2553568946 cites W1922661470 @default.
- W2553568946 cites W1965157206 @default.
- W2553568946 cites W1965281877 @default.
- W2553568946 cites W1965410387 @default.
- W2553568946 cites W1966564846 @default.
- W2553568946 cites W1967802833 @default.
- W2553568946 cites W1969360744 @default.
- W2553568946 cites W1970339183 @default.
- W2553568946 cites W1973017365 @default.
- W2553568946 cites W1973725190 @default.
- W2553568946 cites W1974059924 @default.
- W2553568946 cites W1976964790 @default.
- W2553568946 cites W1978968660 @default.
- W2553568946 cites W1979440527 @default.
- W2553568946 cites W1979812265 @default.
- W2553568946 cites W1980743267 @default.
- W2553568946 cites W1981068608 @default.
- W2553568946 cites W1981290819 @default.
- W2553568946 cites W1982603620 @default.
- W2553568946 cites W1983460993 @default.
- W2553568946 cites W1984433201 @default.
- W2553568946 cites W1989281114 @default.
- W2553568946 cites W1993115402 @default.
- W2553568946 cites W1998536076 @default.
- W2553568946 cites W2001286107 @default.
- W2553568946 cites W2001780798 @default.
- W2553568946 cites W2001837729 @default.
- W2553568946 cites W2002315827 @default.
- W2553568946 cites W2002855657 @default.
- W2553568946 cites W2003050030 @default.
- W2553568946 cites W2004838336 @default.
- W2553568946 cites W2005949634 @default.
- W2553568946 cites W2006097513 @default.
- W2553568946 cites W2009886857 @default.
- W2553568946 cites W2010867675 @default.
- W2553568946 cites W2011942829 @default.
- W2553568946 cites W2014860098 @default.
- W2553568946 cites W2015796780 @default.
- W2553568946 cites W2016776882 @default.
- W2553568946 cites W2018286352 @default.
- W2553568946 cites W2019157776 @default.
- W2553568946 cites W2019323840 @default.
- W2553568946 cites W2019593540 @default.
- W2553568946 cites W2020854296 @default.
- W2553568946 cites W2020857992 @default.
- W2553568946 cites W2021558950 @default.
- W2553568946 cites W2023316892 @default.
- W2553568946 cites W2023427658 @default.
- W2553568946 cites W2024986033 @default.
- W2553568946 cites W2028326666 @default.
- W2553568946 cites W2028945975 @default.
- W2553568946 cites W2029536633 @default.
- W2553568946 cites W2029696463 @default.
- W2553568946 cites W2034986957 @default.
- W2553568946 cites W2037349407 @default.
- W2553568946 cites W2038970717 @default.
- W2553568946 cites W2041263494 @default.
- W2553568946 cites W2041400512 @default.
- W2553568946 cites W2045332624 @default.
- W2553568946 cites W2045414448 @default.
- W2553568946 cites W2050688574 @default.
- W2553568946 cites W2056994401 @default.
- W2553568946 cites W2057210535 @default.
- W2553568946 cites W2061670660 @default.
- W2553568946 cites W2065220128 @default.
- W2553568946 cites W2069637351 @default.
- W2553568946 cites W2072555538 @default.
- W2553568946 cites W2073483289 @default.
- W2553568946 cites W2073759231 @default.
- W2553568946 cites W2075136474 @default.
- W2553568946 cites W2077264573 @default.
- W2553568946 cites W2081587092 @default.
- W2553568946 cites W2082161467 @default.
- W2553568946 cites W2082645493 @default.
- W2553568946 cites W2083345429 @default.
- W2553568946 cites W2086265207 @default.
- W2553568946 cites W2086609648 @default.
- W2553568946 cites W2086810512 @default.
- W2553568946 cites W2089108952 @default.
- W2553568946 cites W2089361444 @default.
- W2553568946 cites W2089425432 @default.