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- W2553573268 abstract "Background IL-31 is a newly-described cytokine mainly produced by activated Th2 cells. IL-31 acts through IL31-RA and oncostatin heterodimeric receptors that activate STAT3 and STAT5. So far, IL31 has been mainly involved in airway hypersensitivity and atopic dermatitis. More recent data suggest its involvement in psoriasis, inflammatory bowel disease and osteoporosis. Objectives We aimed to assess IL-31 serum levels in patients with recent onset axial spondyloarthritis (SpA) from DESIR cohort. Methods The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early inflammatory back pain (IBP) (duration >3 months and Results IL31 was significantly increased (p Conclusions IL31 serum levels are correlated with sC40L suggesting the role of activated T-cells in IL-31 expression. IL31 is also significantly correlated with the Wnt signaling inhibitory protein DKK-1. Increased levels of IL-31 might protect patients from structural damages but are also associated with low bone density. These preliminary results regarding IL-31 mediated bone effects in DESIR cohort need to be confirmed in more severe forms of the disease. Disclosure of Interest None declared" @default.
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- W2553573268 date "2016-06-01" @default.
- W2553573268 modified "2023-10-14" @default.
- W2553573268 title "FRI0432 Increase in Il-31 Serum Level in Recent Spondyloarthritis: Data from The Desir Cohort" @default.
- W2553573268 doi "https://doi.org/10.1136/annrheumdis-2016-eular.5835" @default.
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