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• W2553584996 abstract "Background Clinical trials have demonstrated the efficacy of Tocilizumab (TCZ) for patients with rheumatoid arthritis (RA). Several studies have demonstrated that dose tapering of TNF-inhibitors is a feasible therapeutic option in rheumatic patients with low disease activity (LDA). Nevertheless, few reports analyse the effectiveness of dose-tapering of TCZ. Objectives To evaluate the clinical outcome and incidence of flares in patients with RA in remission or LDA under a tapering strategy with TCZ and to analyse the influence of the tapering on serum drug levels. Methods Of a cohort of 34 adult patients with RA under therapy with TCZ, 13 patients with sustained LDA or remission (DAS 28-ESR Results The baseline demographic and clinical characteristics are shown in Table 1. No differences in the clinical activity (DAS28: 2,28± 0,8 at V0 vs 2,5±0,7 at LV, p=0,25; CDAI 4,71: ±5,1 at V0 vs 5,71±5,1 at LV p=0,08; SDAI (4,99±5,3 at V0 vs 5,0 ±4,8 at LV, p=0,052), number of swollen joints (1,69±3,2 at V0 vs 1,46±1,8 at LV; p=0,091) and tender joints (0,69± 1,1 at V0 vs 0,62±0,96 at LV; p=0,243) and acute-phase reactants (CRP: 0,48±0,6 at V0 vs 0,54±0,6 at LV, p=0,219; ESR: 7,69±3,1 at V0 vs 10,3±5,4 at LV, p=0,152) between V0 and LV were observed. The decrease of drug levels between V0 and LV was not significant (15,4±9,31 vs 3,02±5,99, p=0,867). During the follow-up period, 6 (43%) patients presented flares. The number of flares after the tapering strategy was 1,2±1,6 and the time to the first flare was 1±0,4 years. The following clinical and disease activity data and serum TCZ levels were registered at the worst flare: STJ: 6,7± 7,4 and TJC: 1,83±1,2; DAS28: 3,99±0,6, CDAI: 14,7± 8,2 and SDAI: 14,5±9,08; TCZ levels: 0,86±1,78. Most patients after having a flare (4/6) reached remission or LDA at the end of the study, and no significant differences in LDA were observed between those with or without flares (DAS-28 LV Conclusions The tapering strategy in patients with RA with LDA or remission receiving TCZ appears to be feasible, resulting in a low proportion of patients with flares and a good longterm clinical disease activity control. Disclosure of Interest C. Tornero Grant/research support from: Funded by an unrestricted medical grant from Pfizer., C. Plasencia: None declared, D. Pascual: None declared, T. Jurado: None declared, I. Monjo: None declared, M. B. Paredes: None declared, E. Moral: None declared, A. Pieren: None declared, L. Nuno: None declared, G. Bonilla: None declared, D. Peitedo: None declared, E. M.Mola: None declared, A. Balsa: None declared" @default.
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• W2553584996 date "2016-06-01" @default.
• W2553584996 modified "2023-09-23" @default.
• W2553584996 title "AB0340 Tapering Strategy in Patients with Rheumatoid Arthritis Receiving Tocilizumab" @default.
• W2553584996 doi "https://doi.org/10.1136/annrheumdis-2016-eular.5455" @default.
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