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• W2553589340 abstract "The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in regulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level REV-ERBα modulates the expression of FGF21 via the liver specific hepatic nuclear factor 6 (HNF6). We conclude, that REV-ERBα regulates metabolism and reproduction at least in part via regulation of Fgf21." @default.
• W2553589340 created "2016-11-30" @default.
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• W2553589340 date "2016-01-01" @default.
• W2553589340 modified "2023-09-27" @default.
• W2553589340 title "REV-ERBα regulates <i>Fgf21</i> expression in the liver via hepatic nuclear factor 6" @default.
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• W2553589340 doi "https://doi.org/10.1242/bio.021519" @default.
• W2553589340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5278426" @default.
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