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- W2553596300 abstract "Summary The hypoglycaemic activity of the alcoholic extract of roots of Rubia cordifolia (RCAE, 50, 100 and 200 mg/kg, p.o.) was studied in normal, glucose fed and alloxan- induced diabetic rats. The normal rats were treated with single dose of RCAE (200 mg/kg, p.o.) reduced the blood glucose by 20.4 %. The rats pre-treated with RCAE (200 mg/kg, p.o.) improved oral glucose tolerance by 124.7 % at ½ h compared to glucose fed rats, exogenously injected insulin (1 IU/kg, s.c.) with RCAE (200 mg/kg, p.o.) caused 26% potentiation of hypoglycaemic effect at 6 h as compared with alone insulin treatment. A single oral dose of RCAE (200 mg/kg) to alloxan- induced diabetic rats showed 12.5 % reduction in blood glucose at 4 h. After repeated oral administration of RCAE (200 mg/kg) in diabetic rats for two weeks, the blood glucose reduced by 27.1 %, serum total cholesterol by 19.8 % and serum triglyceride by 16.6 % and serum albumin concentration increased by 40.3 % as compared to diabetic control group. The hypoglycaemic activity of RCAE was compared with an oral hypoglycaemic agent, glibenclamide." @default.
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- W2553596300 date "2007-01-01" @default.
- W2553596300 modified "2023-09-24" @default.
- W2553596300 title "HYPOGLYCAEMIC ACTIVITY OF ROOTS OF RUBIA CORDIFOLIA IN NORMAL AND DIABETIC RATS" @default.
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