Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553600900> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2553600900 abstract "Abstract Age adjusted incidence of Hodgkin’s Lymphoma (HL) is markedly higher in Saudi Arabia than in the United States. For example, HL accounts for 10.5% of all neoplasia in children 15 years and younger in Saudi Arabia. EBV virus infection, which can induce HL transformation has been suspected to cause high HL incidence in developing countries. To investigate the role of EBV for the high frequency of HL in Saudi Arabia, we analyzed 265 HL from Saudi Arabia and 58 HL from Europe for EBV infection by in situ hybridization with fluoresce in-conjugated Epstein-Barr virus (EBER) on tissue microarray (TMA) sections. All Saudi and European HL were analyzed in one staining run under identical conditions. Unexpectedly, our data show only minor, statistically insignificant differences in EBV infection rates between Saudi (64 out of 150 informative cases; 42.6%) and European HL (11 out of 30 informative cases; 33%; p=0.5). Within the Arabian population, EBV positivity was more frequent in 79 children (53%) than among 133 adults (36%; p=0.015). EBV positivity was also linked to high stage with EBV positivity in 36% of 69 stage I/II and 64% of 73 stage III/IV tumors (p=0.009). EBV infection was most frequently seen in mixed cellularity HL (63% of 27 cases). This was significantly more frequent than in nodular sclerosing HL (39% of 136; p=0.02). Interestingly, EBV positivity was associated with good prognosis in Saudi childhood HL (p=0.016) but with poor prognosis in Saudi adulthood HL (p=0.0048). In conclusion, our data strongly suggest that EBV is not the main cause for the high prevalence of HL in Middle East countries. Among others, this would be consistent with a major role of genetic susceptibility genes for HL in these populations. Saudi Arabia with high consanguinity and large families would be ideal to search for HL susceptibility genes." @default.
- W2553600900 created "2016-11-30" @default.
- W2553600900 creator A5002529117 @default.
- W2553600900 creator A5007249612 @default.
- W2553600900 creator A5018975121 @default.
- W2553600900 creator A5030728756 @default.
- W2553600900 creator A5039411132 @default.
- W2553600900 creator A5039935804 @default.
- W2553600900 creator A5049791450 @default.
- W2553600900 creator A5074062351 @default.
- W2553600900 creator A5080396108 @default.
- W2553600900 creator A5084116270 @default.
- W2553600900 creator A5086499788 @default.
- W2553600900 date "2004-11-16" @default.
- W2553600900 modified "2023-09-26" @default.
- W2553600900 title "Epstein-Barr Virus Infection Is Not the Sole Cause of High Prevalence for Hodgkin’s Lymphoma in Saudi Arabia." @default.
- W2553600900 doi "https://doi.org/10.1182/blood.v104.11.3120.3120" @default.
- W2553600900 hasPublicationYear "2004" @default.
- W2553600900 type Work @default.
- W2553600900 sameAs 2553600900 @default.
- W2553600900 citedByCount "0" @default.
- W2553600900 crossrefType "journal-article" @default.
- W2553600900 hasAuthorship W2553600900A5002529117 @default.
- W2553600900 hasAuthorship W2553600900A5007249612 @default.
- W2553600900 hasAuthorship W2553600900A5018975121 @default.
- W2553600900 hasAuthorship W2553600900A5030728756 @default.
- W2553600900 hasAuthorship W2553600900A5039411132 @default.
- W2553600900 hasAuthorship W2553600900A5039935804 @default.
- W2553600900 hasAuthorship W2553600900A5049791450 @default.
- W2553600900 hasAuthorship W2553600900A5074062351 @default.
- W2553600900 hasAuthorship W2553600900A5080396108 @default.
- W2553600900 hasAuthorship W2553600900A5084116270 @default.
- W2553600900 hasAuthorship W2553600900A5086499788 @default.
- W2553600900 hasConcept C120665830 @default.
- W2553600900 hasConcept C121332964 @default.
- W2553600900 hasConcept C126322002 @default.
- W2553600900 hasConcept C142724271 @default.
- W2553600900 hasConcept C146357865 @default.
- W2553600900 hasConcept C151730666 @default.
- W2553600900 hasConcept C203014093 @default.
- W2553600900 hasConcept C2522874641 @default.
- W2553600900 hasConcept C2779338263 @default.
- W2553600900 hasConcept C2780494569 @default.
- W2553600900 hasConcept C2781375147 @default.
- W2553600900 hasConcept C2908647359 @default.
- W2553600900 hasConcept C61511704 @default.
- W2553600900 hasConcept C71924100 @default.
- W2553600900 hasConcept C86803240 @default.
- W2553600900 hasConcept C90924648 @default.
- W2553600900 hasConcept C99454951 @default.
- W2553600900 hasConceptScore W2553600900C120665830 @default.
- W2553600900 hasConceptScore W2553600900C121332964 @default.
- W2553600900 hasConceptScore W2553600900C126322002 @default.
- W2553600900 hasConceptScore W2553600900C142724271 @default.
- W2553600900 hasConceptScore W2553600900C146357865 @default.
- W2553600900 hasConceptScore W2553600900C151730666 @default.
- W2553600900 hasConceptScore W2553600900C203014093 @default.
- W2553600900 hasConceptScore W2553600900C2522874641 @default.
- W2553600900 hasConceptScore W2553600900C2779338263 @default.
- W2553600900 hasConceptScore W2553600900C2780494569 @default.
- W2553600900 hasConceptScore W2553600900C2781375147 @default.
- W2553600900 hasConceptScore W2553600900C2908647359 @default.
- W2553600900 hasConceptScore W2553600900C61511704 @default.
- W2553600900 hasConceptScore W2553600900C71924100 @default.
- W2553600900 hasConceptScore W2553600900C86803240 @default.
- W2553600900 hasConceptScore W2553600900C90924648 @default.
- W2553600900 hasConceptScore W2553600900C99454951 @default.
- W2553600900 hasLocation W25536009001 @default.
- W2553600900 hasOpenAccess W2553600900 @default.
- W2553600900 hasPrimaryLocation W25536009001 @default.
- W2553600900 hasRelatedWork W141443462 @default.
- W2553600900 hasRelatedWork W1512641202 @default.
- W2553600900 hasRelatedWork W2018288464 @default.
- W2553600900 hasRelatedWork W2042712871 @default.
- W2553600900 hasRelatedWork W2109463602 @default.
- W2553600900 hasRelatedWork W2135756723 @default.
- W2553600900 hasRelatedWork W2321237021 @default.
- W2553600900 hasRelatedWork W2417530351 @default.
- W2553600900 hasRelatedWork W2964960998 @default.
- W2553600900 hasRelatedWork W3031059424 @default.
- W2553600900 isParatext "false" @default.
- W2553600900 isRetracted "false" @default.
- W2553600900 magId "2553600900" @default.
- W2553600900 workType "article" @default.