FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553610399> ?p ?o ?g. }

• W2553610399 endingPage "4181" @default.
• W2553610399 startingPage "4181" @default.
• W2553610399 abstract "Abstract Purpose: Maternal immune thrombocytopenic purpura (ITP) accounts for 5% of all cases of pregnancy associated thrombocytopenia and is a common cause of neonatal thrombo­cytopenia. One of the common mechanism involves transfer of IgG autoantibodies against platelet receptors which are found in the blood samples of affected patients. The neonatal thrombocytopenia usually subsides within 2 months. The autoantibodies are often of the IgG type and therefore can cross the placenta and cause fetal and/or neonatal thrombocytopenia. Recently we observed persistence of neonatal ITP which disappeared following discontinuation of breast feeding. The aim of our current work was to discern whether breast milk of mothers with ITP contains anti-platelet antibodies and whether these antibodies may be the cause for persistent neonatal ITP. Methods: Breast milk samples were collected from 12 women with ITP. Six of them were thrombocytopenic during pregnancy and their neonates also had thrombocytopenia. The remaining 6 mothers had a history of ITP but not during the current pregnancy, and neither did their neonates. As controls, breast milk from 8 healthy women was also examinied. The presence of anti-platelet antibodies were evaluated by incubating washed platelets from healthy donors with breast milk or extracted milk – Ig. The type of immune globulin was defined by flow cytometry using fluorescence conjugated anti-human IgA, IgG or total Ig antibodies. To prove that the antibodies were against an antigen that is platelet specific and not against HLA epitopes, we also tested the samples on cultured cells expressing the fibrinogen receptor, αIIbβ3, and compared the results to mock cells (transfected with empty vectors). Results: In the cases of women with active ITP, 3 were positive for anti-platelet antibodies, 2 were inconclusive and one was negative. In the mothers with a history of ITP, 1 was positive, 1 was inconclusive and 4 were negative. No anti-platelet antibodies were found in breast milk of healthy women. In all 6 cases of active ITP, the cell cultured assay for the fibrinogen receptor αIIbβ3 was positive, indicating that there were anti platelet specific antibodies in their milk. Of the 6 neonates of mothers with active ITP, 4 of them required treatment with oral steroids, and the average time to resolution of thrombocytopenia was 3.5 months. Conclusion: This study demonstrates that breastmilk of women with active ITP contains anti platelet specific antibodies. The presence of these antibodies demonstrated an association with persistant and prolonged neonatal thrombocytopenia. Disclosures No relevant conflicts of interest to declare." @default.
• W2553610399 created "2016-11-30" @default.
• W2553610399 creator A5005499641 @default.
• W2553610399 creator A5006537917 @default.
• W2553610399 creator A5014707117 @default.
• W2553610399 creator A5021847528 @default.
• W2553610399 creator A5046851276 @default.
• W2553610399 creator A5053577026 @default.
• W2553610399 creator A5085978729 @default.
• W2553610399 date "2014-12-06" @default.
• W2553610399 modified "2023-09-28" @default.
• W2553610399 title "Breast Milk from Immune Thrombocytopenic Mothers Can Contain Anti Platelet Antibodies That Are Associated with Persistent Thrombocytopenia in Neonates" @default.
• W2553610399 doi "https://doi.org/10.1182/blood.v124.21.4181.4181" @default.
• W2553610399 hasPublicationYear "2014" @default.
• W2553610399 type Work @default.
• W2553610399 sameAs 2553610399 @default.
• W2553610399 citedByCount "0" @default.
• W2553610399 crossrefType "journal-article" @default.
• W2553610399 hasAuthorship W2553610399A5005499641 @default.
• W2553610399 hasAuthorship W2553610399A5006537917 @default.
• W2553610399 hasAuthorship W2553610399A5014707117 @default.
• W2553610399 hasAuthorship W2553610399A5021847528 @default.
• W2553610399 hasAuthorship W2553610399A5046851276 @default.
• W2553610399 hasAuthorship W2553610399A5053577026 @default.
• W2553610399 hasAuthorship W2553610399A5085978729 @default.
• W2553610399 hasConcept C126322002 @default.
• W2553610399 hasConcept C147483822 @default.
• W2553610399 hasConcept C159654299 @default.
• W2553610399 hasConcept C163764329 @default.
• W2553610399 hasConcept C172680121 @default.
• W2553610399 hasConcept C203014093 @default.
• W2553610399 hasConcept C2775871700 @default.
• W2553610399 hasConcept C2779234561 @default.
• W2553610399 hasConcept C2779771385 @default.
• W2553610399 hasConcept C2779989375 @default.
• W2553610399 hasConcept C54355233 @default.
• W2553610399 hasConcept C55493867 @default.
• W2553610399 hasConcept C71924100 @default.
• W2553610399 hasConcept C86803240 @default.
• W2553610399 hasConcept C8891405 @default.
• W2553610399 hasConcept C89560881 @default.
• W2553610399 hasConceptScore W2553610399C126322002 @default.
• W2553610399 hasConceptScore W2553610399C147483822 @default.
• W2553610399 hasConceptScore W2553610399C159654299 @default.
• W2553610399 hasConceptScore W2553610399C163764329 @default.
• W2553610399 hasConceptScore W2553610399C172680121 @default.
• W2553610399 hasConceptScore W2553610399C203014093 @default.
• W2553610399 hasConceptScore W2553610399C2775871700 @default.
• W2553610399 hasConceptScore W2553610399C2779234561 @default.
• W2553610399 hasConceptScore W2553610399C2779771385 @default.
• W2553610399 hasConceptScore W2553610399C2779989375 @default.
• W2553610399 hasConceptScore W2553610399C54355233 @default.
• W2553610399 hasConceptScore W2553610399C55493867 @default.
• W2553610399 hasConceptScore W2553610399C71924100 @default.
• W2553610399 hasConceptScore W2553610399C86803240 @default.
• W2553610399 hasConceptScore W2553610399C8891405 @default.
• W2553610399 hasConceptScore W2553610399C89560881 @default.
• W2553610399 hasIssue "21" @default.
• W2553610399 hasLocation W25536103991 @default.
• W2553610399 hasOpenAccess W2553610399 @default.
• W2553610399 hasPrimaryLocation W25536103991 @default.
• W2553610399 hasRelatedWork W1500125171 @default.
• W2553610399 hasRelatedWork W1785077700 @default.
• W2553610399 hasRelatedWork W1973894832 @default.
• W2553610399 hasRelatedWork W1996992846 @default.
• W2553610399 hasRelatedWork W2005154809 @default.
• W2553610399 hasRelatedWork W2015814192 @default.
• W2553610399 hasRelatedWork W2019235085 @default.
• W2553610399 hasRelatedWork W2034294101 @default.
• W2553610399 hasRelatedWork W2067331360 @default.
• W2553610399 hasRelatedWork W2068175747 @default.
• W2553610399 hasRelatedWork W2078123555 @default.
• W2553610399 hasRelatedWork W2156948660 @default.
• W2553610399 hasRelatedWork W2398376574 @default.
• W2553610399 hasRelatedWork W2398973329 @default.
• W2553610399 hasRelatedWork W2408257387 @default.
• W2553610399 hasRelatedWork W2416236445 @default.
• W2553610399 hasRelatedWork W2467602300 @default.
• W2553610399 hasRelatedWork W2472008663 @default.
• W2553610399 hasRelatedWork W2577130023 @default.
• W2553610399 hasRelatedWork W2979681899 @default.
• W2553610399 hasVolume "124" @default.
• W2553610399 isParatext "false" @default.
• W2553610399 isRetracted "false" @default.
• W2553610399 magId "2553610399" @default.
• W2553610399 workType "article" @default.