FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553614503> ?p ?o ?g. }

• W2553614503 abstract "Human papillomaviruses (HPVs) replicate in the cutaneous and mucosal epithelia, and the infectious cycle is synchronous with the differentiation program of the host keratinocytes. The virus initially infects dividing cells in the lower layers of the epithelium, where it establishes a persistent infection. The viral genome is maintained as a low-copy-number, extrachromosomal element in these proliferating cells but switches to the late stage of the life cycle in differentiated cells. The cellular chromatin adaptor protein Brd4 is involved in several stages and processes of the viral life cycle. In concert with the viral transcriptional regulator E2, Brd4 can repress transcription from the early viral promoter. Brd4 and E2 form a complex with the viral genome that associates with host chromosomes to partition the viral genome in dividing cells; Brd4 also localizes to active sites of productive HPV DNA replication. However, because of the difficulties in producing HPV viral particles, the role of Brd4 in modulating viral transcription and replication at the initial stage of infection is unclear. In this study, we have used an HPV18 quasivirus-based genome delivery system to assess the role of Brd4 in the initial infectivity of primary human keratinocytes. We show that, upon infection of primary human keratinocytes with HPV18 quasivirus, Brd4 activates viral transcription and replication. Furthermore, this activation is independent of the functional interaction between Brd4 and the HPV18 E2 protein.HPVs lack encapsidated proteins and so rely exquisitely on host cellular factors to initiate their gene expression programs in newly infected cells. Brd4 is an important cellular chromatin adaptor molecule that normally activates host transcription initiation and elongation. In this study, we further optimize and utilize a quasivirus infection system to show that Brd4 activates HPV18 transcription at early stages of infection. HPVs are important human pathogens causing a wide range of cutaneous and tumorigenic morbidities. Therefore, specifically targeting this protein could provide a new target of therapeutic prevention of establishment of HPV infections." @default.
• W2553614503 created "2016-11-30" @default.
• W2553614503 creator A5002817894 @default.
• W2553614503 creator A5014212306 @default.
• W2553614503 creator A5027381296 @default.
• W2553614503 creator A5078465675 @default.
• W2553614503 date "2016-12-30" @default.
• W2553614503 modified "2023-10-18" @default.
• W2553614503 title "Brd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes" @default.
• W2553614503 cites W1526757395 @default.
• W2553614503 cites W1584453803 @default.
• W2553614503 cites W1672426070 @default.
• W2553614503 cites W1696730408 @default.
• W2553614503 cites W1722478811 @default.
• W2553614503 cites W1953491779 @default.
• W2553614503 cites W1966544242 @default.
• W2553614503 cites W1992127633 @default.
• W2553614503 cites W1995228478 @default.
• W2553614503 cites W1998710947 @default.
• W2553614503 cites W2001202839 @default.
• W2553614503 cites W2005326726 @default.
• W2553614503 cites W2009959680 @default.
• W2553614503 cites W2012616842 @default.
• W2553614503 cites W2016775797 @default.
• W2553614503 cites W2032572462 @default.
• W2553614503 cites W2036122512 @default.
• W2553614503 cites W2038692465 @default.
• W2553614503 cites W2052692973 @default.
• W2553614503 cites W2056601517 @default.
• W2553614503 cites W2062594287 @default.
• W2553614503 cites W2063475378 @default.
• W2553614503 cites W2068965703 @default.
• W2553614503 cites W2069377953 @default.
• W2553614503 cites W2073904721 @default.
• W2553614503 cites W2074766470 @default.
• W2553614503 cites W2088025605 @default.
• W2553614503 cites W2090525634 @default.
• W2553614503 cites W2090788819 @default.
• W2553614503 cites W2093340258 @default.
• W2553614503 cites W2101026209 @default.
• W2553614503 cites W2102795910 @default.
• W2553614503 cites W2104459561 @default.
• W2553614503 cites W2105810648 @default.
• W2553614503 cites W2106682089 @default.
• W2553614503 cites W2107971082 @default.
• W2553614503 cites W2111256335 @default.
• W2553614503 cites W2112537938 @default.
• W2553614503 cites W2117002390 @default.
• W2553614503 cites W2137970726 @default.
• W2553614503 cites W2140856180 @default.
• W2553614503 cites W2142006870 @default.
• W2553614503 cites W2145340862 @default.
• W2553614503 cites W2150088870 @default.
• W2553614503 cites W2152979497 @default.
• W2553614503 cites W2154446973 @default.
• W2553614503 cites W2155766301 @default.
• W2553614503 cites W2157855883 @default.
• W2553614503 cites W2160281011 @default.
• W2553614503 cites W2161945723 @default.
• W2553614503 cites W2166834626 @default.
• W2553614503 cites W2167593547 @default.
• W2553614503 cites W2285974166 @default.
• W2553614503 cites W2418509183 @default.
• W2553614503 cites W46899889 @default.
• W2553614503 doi "https://doi.org/10.1128/mbio.01644-16" @default.
• W2553614503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5120138" @default.
• W2553614503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27879331" @default.
• W2553614503 hasPublicationYear "2016" @default.
• W2553614503 type Work @default.
• W2553614503 sameAs 2553614503 @default.
• W2553614503 citedByCount "30" @default.
• W2553614503 countsByYear W25536145032016 @default.
• W2553614503 countsByYear W25536145032017 @default.
• W2553614503 countsByYear W25536145032018 @default.
• W2553614503 countsByYear W25536145032019 @default.
• W2553614503 countsByYear W25536145032020 @default.
• W2553614503 countsByYear W25536145032021 @default.
• W2553614503 countsByYear W25536145032022 @default.
• W2553614503 countsByYear W25536145032023 @default.
• W2553614503 crossrefType "journal-article" @default.
• W2553614503 hasAuthorship W2553614503A5002817894 @default.
• W2553614503 hasAuthorship W2553614503A5014212306 @default.
• W2553614503 hasAuthorship W2553614503A5027381296 @default.
• W2553614503 hasAuthorship W2553614503A5078465675 @default.
• W2553614503 hasBestOaLocation W25536145031 @default.
• W2553614503 hasConcept C104317684 @default.
• W2553614503 hasConcept C138885662 @default.
• W2553614503 hasConcept C140704245 @default.
• W2553614503 hasConcept C159047783 @default.
• W2553614503 hasConcept C179926584 @default.
• W2553614503 hasConcept C2522874641 @default.
• W2553614503 hasConcept C25897203 @default.
• W2553614503 hasConcept C2779634854 @default.
• W2553614503 hasConcept C41895202 @default.
• W2553614503 hasConcept C54355233 @default.
• W2553614503 hasConcept C64927066 @default.
• W2553614503 hasConcept C74401373 @default.
• W2553614503 hasConcept C83640560 @default.
• W2553614503 hasConcept C86339819 @default.
• W2553614503 hasConcept C86803240 @default.

• next