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- W2553617740 abstract "Kidney transplantation is one treatment for end-stage renal disease. Transplant rejection is typically evaluated with an invasive biopsy. Noninvasive methods for evaluating renal transplants would be beneficial for frequent evaluation. We propose the use of shear wave elastography (SWE) to evaluate viscoelastic properties in renal transplants. Further, we also use acoustoelasticity to measure the nonlinear modulus of the renal transplants. Acoustoelasticity is the phenomenon where the shear wave velocity (SWV) in a material varies with applied stress and is quantified by a nonlinear modulus, A. By applying pressure with the ultrasound transducer, stress is applied to the kidney under investigation and B-mode imaging was used to measure induced strain and SWE was used to make measurements of SWV. Using relationships involving the measured strain and shear moduli at different compression levels, we can obtain estimates of A. In our ongoing study, we use a General Electric Logiq E9 to perform SWE measurements in renal transplant patients coming for protocol biopsies. We have studied 63 patients with SWE to quantify viscoelastic properties of the transplanted kidney. We have obtained data from 19 patients for estimation of the nonlinear modulus, A. We compared the measured viscoelastic and nonlinear shear parameters with clinical variables such as the serum creatinine, Banff biopsy scores, and resistive index. We continue to evaluate these methods and their efficacy as indicators for transplant rejection." @default.
- W2553617740 created "2016-11-30" @default.
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- W2553617740 date "2016-10-01" @default.
- W2553617740 modified "2023-09-26" @default.
- W2553617740 title "Compressing and shearing the transplanted kidney" @default.
- W2553617740 doi "https://doi.org/10.1121/1.4969830" @default.
- W2553617740 hasPublicationYear "2016" @default.
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