FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553624637> ?p ?o ?g. }

• W2553624637 endingPage "6" @default.
• W2553624637 startingPage "1" @default.
• W2553624637 abstract "Treatment of patients with large bone defects is a complex clinical problem. We have initiated the first clinical study of a gene-activated bone substitute composed of the collagen-hydroxyapatite scaffold and plasmid DNA encoding vascular endothelial growth factor. The first patient with two nonunions of previously reconstructed mandible was enrolled into the study. Scar tissues were excised; bone defects (5–14 mm) between the mandibular fragments and nonvascularized rib-bone autograft were filled in with the gene-activated bone substitute. No adverse events were observed during 12 months of follow-up. In 3 months, the average density of newly formed tissues within the implantation zone was 402.21 ± 84.40 and 447.68 ± 106.75 HU in the frontal and distal regions, respectively, which correlated with the density of spongy bone. Complete distal bone defect repair with vestibular and lingual cortical plates formation was observed in 6 and 12 months after surgery; thereby the posterior nonunion was successfully eliminated. However, there was partial resorption of the proximal edge of the autograft entailed to relapse of the anterior nonunion. Thus, the first clinical data on the safety and efficacy of the gene-activated bone substitute were obtained. Given a high complexity of the clinical situation the treatment, results might be considered as promising. NCT02293031 ." @default.
• W2553624637 created "2016-11-30" @default.
• W2553624637 creator A5054556936 @default.
• W2553624637 creator A5080505580 @default.
• W2553624637 creator A5086806279 @default.
• W2553624637 creator A5086826644 @default.
• W2553624637 creator A5087180875 @default.
• W2553624637 date "2016-01-01" @default.
• W2553624637 modified "2023-10-02" @default.
• W2553624637 title "World’s First Clinical Case of Gene-Activated Bone Substitute Application" @default.
• W2553624637 cites W1980751526 @default.
• W2553624637 cites W1999730602 @default.
• W2553624637 cites W2001723304 @default.
• W2553624637 cites W2003288197 @default.
• W2553624637 cites W2014077602 @default.
• W2553624637 cites W2050724276 @default.
• W2553624637 cites W2059841303 @default.
• W2553624637 cites W2063142742 @default.
• W2553624637 cites W2065381738 @default.
• W2553624637 cites W2066257355 @default.
• W2553624637 cites W2068511668 @default.
• W2553624637 cites W2103083210 @default.
• W2553624637 cites W2111035980 @default.
• W2553624637 cites W2144438594 @default.
• W2553624637 cites W2154271309 @default.
• W2553624637 cites W2168748728 @default.
• W2553624637 cites W2200600403 @default.
• W2553624637 cites W2320829119 @default.
• W2553624637 cites W2329984659 @default.
• W2553624637 cites W2395672168 @default.
• W2553624637 cites W93742189 @default.
• W2553624637 doi "https://doi.org/10.1155/2016/8648949" @default.
• W2553624637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5116519" @default.
• W2553624637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27891264" @default.
• W2553624637 hasPublicationYear "2016" @default.
• W2553624637 type Work @default.
• W2553624637 sameAs 2553624637 @default.
• W2553624637 citedByCount "17" @default.
• W2553624637 countsByYear W25536246372017 @default.
• W2553624637 countsByYear W25536246372018 @default.
• W2553624637 countsByYear W25536246372019 @default.
• W2553624637 countsByYear W25536246372020 @default.
• W2553624637 countsByYear W25536246372021 @default.
• W2553624637 countsByYear W25536246372022 @default.
• W2553624637 countsByYear W25536246372023 @default.
• W2553624637 crossrefType "journal-article" @default.
• W2553624637 hasAuthorship W2553624637A5054556936 @default.
• W2553624637 hasAuthorship W2553624637A5080505580 @default.
• W2553624637 hasAuthorship W2553624637A5086806279 @default.
• W2553624637 hasAuthorship W2553624637A5086826644 @default.
• W2553624637 hasAuthorship W2553624637A5087180875 @default.
• W2553624637 hasBestOaLocation W25536246371 @default.
• W2553624637 hasConcept C105702510 @default.
• W2553624637 hasConcept C126322002 @default.
• W2553624637 hasConcept C141071460 @default.
• W2553624637 hasConcept C142724271 @default.
• W2553624637 hasConcept C146562846 @default.
• W2553624637 hasConcept C157369684 @default.
• W2553624637 hasConcept C2779330695 @default.
• W2553624637 hasConcept C2779767645 @default.
• W2553624637 hasConcept C2781451080 @default.
• W2553624637 hasConcept C59822182 @default.
• W2553624637 hasConcept C673006 @default.
• W2553624637 hasConcept C71924100 @default.
• W2553624637 hasConcept C86803240 @default.
• W2553624637 hasConceptScore W2553624637C105702510 @default.
• W2553624637 hasConceptScore W2553624637C126322002 @default.
• W2553624637 hasConceptScore W2553624637C141071460 @default.
• W2553624637 hasConceptScore W2553624637C142724271 @default.
• W2553624637 hasConceptScore W2553624637C146562846 @default.
• W2553624637 hasConceptScore W2553624637C157369684 @default.
• W2553624637 hasConceptScore W2553624637C2779330695 @default.
• W2553624637 hasConceptScore W2553624637C2779767645 @default.
• W2553624637 hasConceptScore W2553624637C2781451080 @default.
• W2553624637 hasConceptScore W2553624637C59822182 @default.
• W2553624637 hasConceptScore W2553624637C673006 @default.
• W2553624637 hasConceptScore W2553624637C71924100 @default.
• W2553624637 hasConceptScore W2553624637C86803240 @default.
• W2553624637 hasLocation W25536246371 @default.
• W2553624637 hasLocation W25536246372 @default.
• W2553624637 hasLocation W25536246373 @default.
• W2553624637 hasLocation W25536246374 @default.
• W2553624637 hasOpenAccess W2553624637 @default.
• W2553624637 hasPrimaryLocation W25536246371 @default.
• W2553624637 hasRelatedWork W1972870474 @default.
• W2553624637 hasRelatedWork W2019102382 @default.
• W2553624637 hasRelatedWork W2059672262 @default.
• W2553624637 hasRelatedWork W2082299443 @default.
• W2553624637 hasRelatedWork W2095935818 @default.
• W2553624637 hasRelatedWork W2149420990 @default.
• W2553624637 hasRelatedWork W2170985328 @default.
• W2553624637 hasRelatedWork W2171154327 @default.
• W2553624637 hasRelatedWork W2317759546 @default.
• W2553624637 hasRelatedWork W2616960925 @default.
• W2553624637 hasVolume "2016" @default.
• W2553624637 isParatext "false" @default.
• W2553624637 isRetracted "false" @default.
• W2553624637 magId "2553624637" @default.

• next