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- W2553640385 abstract "Introduction: PHYSACTO ® has shown improvements in exercise capacity in patients with COPD receiving bronchodilators (BDs) ± exercise training (ExT) added to a self-management behaviour-modification programme (SMBM). Aim: We explored the influence of BDs ± ExT following SMBM on physical activity (PA) and perceived PA-related difficulty and symptoms in PHYSACTO ® (NCT02085161). Methods: A 12-week (wk), randomised, partially double-blind, placebo (P)-controlled, parallel-group trial. Interventions (all with 12-wk SMBM): P; tiotropium (T) 5 µg; T + olodaterol (O) 5/5 µg; T+O 5/5 µg + 8-wk ExT. A triaxial accelerometer assessed PA (steps/day), the Functional Performance Inventory assessed patient-reported difficulty engaging in PA and the Chronic Respiratory Questionnaire assessed PA-related dyspnoea. Results: 303 patients (post-BD FEV 1 : 57 (13) % predicted) were randomised and treated (full analysis set n=274). Change in steps/day at Wk 12 is shown in the Table; no significant gain in PA was seen by adding T+O or T+O + ExT to SMBM, versus SMBM + P. However, PA-related difficulty and dyspnoea significantly decreased at Wk 12 for SMBM + T+O, versus SMBM + P. Conclusions: In moderate to severe COPD, SMBM increased PA and the addition of T+O to SMBM was associated with reduced PA-related difficulty and symptoms when compared to SMBM + P. Funding: Boehringer Ingelheim." @default.
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- W2553640385 date "2016-09-01" @default.
- W2553640385 modified "2023-10-05" @default.
- W2553640385 title "LATE-BREAKING ABSTRACT: Effects of bronchodilator therapy and exercise training, added to a self-management behaviour-modification programme, on physical activity in COPD" @default.
- W2553640385 doi "https://doi.org/10.1183/13993003.congress-2016.pa713" @default.
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