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- W2553642774 abstract " progressive multifocal leukoencephalopathy ● infratentorial ● AIDS ● ataxia Abstract ! Progressive multifocal leukoencephalopathy (PML), manifestation of a JC virus reactivation, is mainly known as supratentorial inflammation due to immunosuppression. The importance and comprehension of this disease, that is terminal in many cases, has increased over the past years as a consequence of new possibilities of medical im- munosuppression and as a consequence of the AIDS pandemia. Treatment mainly aims at im- proving the patient's immunostatus as there is no established specific therapy to date. A 49- year-old HIV-positive man presented with rapid progressive hemiataxia and dysarthria. The diag- nosis of PML could be made using magnetic reso- nance imaging and JC virus PCR testing of cere- brospinal fluid, interestingly first concerning the cerebellum only. In spite of combined antiretrovi- ral medication the disease was lethal within a few weeks. This case report is intended to underline the possibility of a selectively infratentorial mani- festation of PML." @default.
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- W2553642774 date "2013-01-01" @default.
- W2553642774 modified "2023-09-23" @default.
- W2553642774 title "Infratentorielle Progressive Multifokale Leukenze- phalopathie Infratentorial Progressive Multifocal Leukoencephalopathy" @default.
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