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- W2553649546 abstract "Several preclinical studies have shown potential immunemodulatory properties of mesenchymal stem cells (MSC) in type 1 diabetes leading to phase I/II clinical trials. Immune-modulatory properties of MSC have been mainly ascribed to their secretome. The extracellular vesicles (EV) have emerged as paracrine mediators of MSC actions. In fact, MSC-derived EV have been shown to carry proteins and nucleic acids capable to mimic the effect of originating cells. In the present short review we discuss evidences for contribution of EV to the immune-modulatory properties of MSC and mechanisms involved. In particular, EV were shown to inhibit T cell response to the glutamic acid decarboxylase (GAD) islet auto-antigen by inducing a shift of lymphocytes from Th1 to Th2 phenotype." @default.
- W2553649546 created "2016-11-30" @default.
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- W2553649546 date "2015-12-31" @default.
- W2553649546 modified "2023-09-26" @default.
- W2553649546 title "Potential Immune Modulatory Action of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Type 1 Diabetes" @default.
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- W2553649546 doi "https://doi.org/10.23937/2469-570x/1410011" @default.
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