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- W2553696749 abstract "Introduction: The incidence of hypoventilation during induction of bronchoscopic sedation is unknown. Aims and objectives: While induction of sedation, the respiratory drive and muscle tone attenuate, contributing to hypoventilation, which may precede the desired sedative level. We hypothesize that nasal-oral capnography could detect hypoventilation during induction and start bronchoscopy following hypoventilation in spite of sedative level would not compromise the safety and patient satisfaction. Methods: Target controlled infusion of propofol targeted at 2 u g/ml and maintain stable vital signs and sedative levels during bronchoscopy. Patients were randomized to: start bronchoscopy when hypoventilation (hypopnea, successive two breaths of at least 50% reduction of peak wave comparing to baseline or apnea, no wave for 10 seconds) (study group, n=34), or when Observer Assessment of Alertness and Sedation scale 2∼3 (blind to capnography, control group, n=38). The hypoventilation during induction in control group and sedative outcome were recorded. Results: The patient characteristics and procedures performed are similar. Hypoventilation during induction occurred in 73.7% of patients of control group and frequency of hypopnea /apnea was 1 (0∼4) / 0 (0∼3) (median with range). The induction time was significant less in the study group (154.2±136.4 vs. 196.1±110.5 seconds, p=0.02). There is no difference in hypoxemia (41.2 vs 47.4%), hypotension (11.8 vs. 13.2%) and patient satisfaction (100-mm visual analogue scale, 3.3±4.6 vs. 8.0±13.7 mm) between groups. Conclusions: Significant hypoventilation occurred during induction and start bronchoscopy following hypoventilation is feasible." @default.
- W2553696749 created "2016-11-30" @default.
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- W2553696749 date "2016-09-01" @default.
- W2553696749 modified "2023-09-25" @default.
- W2553696749 title "Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation" @default.
- W2553696749 doi "https://doi.org/10.1183/13993003.congress-2016.pa769" @default.
- W2553696749 hasPublicationYear "2016" @default.
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