FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553844028> ?p ?o ?g. }

• W2553844028 endingPage "550" @default.
• W2553844028 startingPage "540" @default.
• W2553844028 abstract "Treatment with omalizumab has shown a positive effect on food allergies, but no dosages are established. Basophil allergen threshold sensitivity (CD-sens) can be used to objectively measure omalizumab treatment efficacy and correlates with the outcome of double-blind placebo-controlled food challenge to peanut.To evaluate whether individualized omalizumab treatment monitored by CD-sens could be an effective intervention for suppression of allergic reactions to peanut.Severely peanut allergic adolescents (n = 23) were treated with omalizumab for 8 weeks, and CD-sens was analysed before and after. Based on whether CD-sens was suppressed after 8 weeks, the patients either were subject to a peanut challenge or received eight more weeks with increased dose of omalizumab, followed by peanut challenge or another 8-week cycle of omalizumab. IgE and IgE-antibodies to peanut and its components were analysed before treatment.After individualized omalizumab treatment (8-24 weeks), all patients continued with an open peanut challenge with no (n = 18) or mild (n = 5) objective allergic symptoms. Patients (n = 15) needing an elevated omalizumab dose (ED) to suppress CD-sens had significantly higher CD-sens values at baseline 1.49 (0.44-20.5) compared to those (n = 8) who managed with normal dose (ND) 0.32 (0.24-5.5) (P < 0.01). Median ratios for Ara h 2 IgE-ab/IgE were significantly higher in the ED group (17%) compared to the ND group (11%).Individually dosed omalizumab, monitored by CD-sens, is an effective and safe treatment for severe peanut allergy. The ratio of IgE-ab to storage protein Ara h 2/IgE as well as CD-sens to peanut may predict the need of a higher omalizumab dose. Clinical trials numbers: EudraCT; 2012-005625-78, ClinicalTrials.gov; NCT02402231." @default.
• W2553844028 created "2016-11-30" @default.
• W2553844028 creator A5018087577 @default.
• W2553844028 creator A5032754184 @default.
• W2553844028 creator A5055342488 @default.
• W2553844028 creator A5063063647 @default.
• W2553844028 creator A5069113791 @default.
• W2553844028 creator A5069502224 @default.
• W2553844028 creator A5087929754 @default.
• W2553844028 creator A5091366467 @default.
• W2553844028 date "2017-01-10" @default.
• W2553844028 modified "2023-10-15" @default.
• W2553844028 title "Individually dosed omalizumab: an effective treatment for severe peanut allergy" @default.
• W2553844028 cites W1491928602 @default.
• W2553844028 cites W1571982287 @default.
• W2553844028 cites W1579441494 @default.
• W2553844028 cites W1971723752 @default.
• W2553844028 cites W1982630532 @default.
• W2553844028 cites W1985824732 @default.
• W2553844028 cites W1986547754 @default.
• W2553844028 cites W1991498260 @default.
• W2553844028 cites W1994095603 @default.
• W2553844028 cites W2012158447 @default.
• W2553844028 cites W2014953142 @default.
• W2553844028 cites W2018189119 @default.
• W2553844028 cites W2027046805 @default.
• W2553844028 cites W2028156173 @default.
• W2553844028 cites W2033975621 @default.
• W2553844028 cites W2034912129 @default.
• W2553844028 cites W2041473883 @default.
• W2553844028 cites W2051807506 @default.
• W2553844028 cites W2072902367 @default.
• W2553844028 cites W2096008082 @default.
• W2553844028 cites W2100042048 @default.
• W2553844028 cites W2106413482 @default.
• W2553844028 cites W2109991665 @default.
• W2553844028 cites W2117748999 @default.
• W2553844028 cites W2117753927 @default.
• W2553844028 cites W2118769673 @default.
• W2553844028 cites W2127707303 @default.
• W2553844028 cites W2132885099 @default.
• W2553844028 cites W2136735111 @default.
• W2553844028 cites W2146384139 @default.
• W2553844028 cites W2159085303 @default.
• W2553844028 doi "https://doi.org/10.1111/cea.12862" @default.
• W2553844028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27883239" @default.
• W2553844028 hasPublicationYear "2017" @default.
• W2553844028 type Work @default.
• W2553844028 sameAs 2553844028 @default.
• W2553844028 citedByCount "48" @default.
• W2553844028 countsByYear W25538440282017 @default.
• W2553844028 countsByYear W25538440282018 @default.
• W2553844028 countsByYear W25538440282019 @default.
• W2553844028 countsByYear W25538440282020 @default.
• W2553844028 countsByYear W25538440282021 @default.
• W2553844028 countsByYear W25538440282022 @default.
• W2553844028 countsByYear W25538440282023 @default.
• W2553844028 crossrefType "journal-article" @default.
• W2553844028 hasAuthorship W2553844028A5018087577 @default.
• W2553844028 hasAuthorship W2553844028A5032754184 @default.
• W2553844028 hasAuthorship W2553844028A5055342488 @default.
• W2553844028 hasAuthorship W2553844028A5063063647 @default.
• W2553844028 hasAuthorship W2553844028A5069113791 @default.
• W2553844028 hasAuthorship W2553844028A5069502224 @default.
• W2553844028 hasAuthorship W2553844028A5087929754 @default.
• W2553844028 hasAuthorship W2553844028A5091366467 @default.
• W2553844028 hasConcept C126322002 @default.
• W2553844028 hasConcept C141105273 @default.
• W2553844028 hasConcept C142724271 @default.
• W2553844028 hasConcept C159654299 @default.
• W2553844028 hasConcept C162156334 @default.
• W2553844028 hasConcept C203014093 @default.
• W2553844028 hasConcept C204787440 @default.
• W2553844028 hasConcept C207480886 @default.
• W2553844028 hasConcept C27081682 @default.
• W2553844028 hasConcept C2776027960 @default.
• W2553844028 hasConcept C2778012357 @default.
• W2553844028 hasConcept C2778564945 @default.
• W2553844028 hasConcept C2780510475 @default.
• W2553844028 hasConcept C71924100 @default.
• W2553844028 hasConcept C90924648 @default.
• W2553844028 hasConceptScore W2553844028C126322002 @default.
• W2553844028 hasConceptScore W2553844028C141105273 @default.
• W2553844028 hasConceptScore W2553844028C142724271 @default.
• W2553844028 hasConceptScore W2553844028C159654299 @default.
• W2553844028 hasConceptScore W2553844028C162156334 @default.
• W2553844028 hasConceptScore W2553844028C203014093 @default.
• W2553844028 hasConceptScore W2553844028C204787440 @default.
• W2553844028 hasConceptScore W2553844028C207480886 @default.
• W2553844028 hasConceptScore W2553844028C27081682 @default.
• W2553844028 hasConceptScore W2553844028C2776027960 @default.
• W2553844028 hasConceptScore W2553844028C2778012357 @default.
• W2553844028 hasConceptScore W2553844028C2778564945 @default.
• W2553844028 hasConceptScore W2553844028C2780510475 @default.
• W2553844028 hasConceptScore W2553844028C71924100 @default.
• W2553844028 hasConceptScore W2553844028C90924648 @default.
• W2553844028 hasFunder F4320309792 @default.
• W2553844028 hasFunder F4320309819 @default.

• next