FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553896360> ?p ?o ?g. }

• W2553896360 abstract "3’-Deoxy-3’-[18F]fluorothymidine ([18F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [18F]FLT-PET/CT combined with a temporal-intensity information-based voxel-clustering approach termed kinetic spatial filtering (KSF) to improve tumour visualisation in patients with locally advanced and metastatic gastro-oesophageal cancer and as a marker of early response to chemotherapy. Dynamic [18F]FLT-PET/CT data were collected before and 3 weeks post first cycle of chemotherapy. Changes in tumour [18F]FLT-PET/CT variables were determined. Response was determined on contrast-enhanced CT after three cycles of therapy using RECIST 1.1. Ten patients were included. Following application of the KSF, visual distinction of all oesophageal and/or gastric tumours was observed in [18F]FLT-PET images. Among the nine patients available for response evaluation (RECIST 1.1), three patients had responded (partial response) and six patients were non-responders (stable disease). There was a significant association between Ki-67 and all baseline [18F]FLT-PET parameters. Area under the curve (AUC) from 0 to 1 min was associated with treatment response. The results of this study indicate that application of the KSF allowed accurate visualisation of both primary and metastatic lesions following imaging with the proliferation marker, [18F]FLT-PET/CT. However, [18F]FLT-PET uptake parameters did not correlate with response. Instead, we observe significant changes in tracer delivery following chemotherapy suggesting that further [18F]FLT-PET/CT studies in this tumour type should be undertaken with caution." @default.
• W2553896360 created "2016-11-30" @default.
• W2553896360 creator A5001831939 @default.
• W2553896360 creator A5007167001 @default.
• W2553896360 creator A5022281453 @default.
• W2553896360 creator A5023030770 @default.
• W2553896360 creator A5039046366 @default.
• W2553896360 creator A5053096526 @default.
• W2553896360 creator A5060311534 @default.
• W2553896360 creator A5070417221 @default.
• W2553896360 creator A5071080479 @default.
• W2553896360 creator A5080620533 @default.
• W2553896360 creator A5090126935 @default.
• W2553896360 date "2016-11-16" @default.
• W2553896360 modified "2023-10-09" @default.
• W2553896360 title "Evaluation of 18F-fluorothymidine positron emission tomography ([18F]FLT-PET/CT) methodology in assessing early response to chemotherapy in patients with gastro-oesophageal cancer" @default.
• W2553896360 cites W1858406656 @default.
• W2553896360 cites W1976594736 @default.
• W2553896360 cites W1978171103 @default.
• W2553896360 cites W2000231546 @default.
• W2553896360 cites W2001268229 @default.
• W2553896360 cites W2007672466 @default.
• W2553896360 cites W2009292054 @default.
• W2553896360 cites W2012196954 @default.
• W2553896360 cites W2018016994 @default.
• W2553896360 cites W2019607817 @default.
• W2553896360 cites W2027437766 @default.
• W2553896360 cites W2034433890 @default.
• W2553896360 cites W2036095734 @default.
• W2553896360 cites W2059219612 @default.
• W2553896360 cites W2078913455 @default.
• W2553896360 cites W2079539804 @default.
• W2553896360 cites W2082132097 @default.
• W2553896360 cites W2085961182 @default.
• W2553896360 cites W2087836177 @default.
• W2553896360 cites W2110961980 @default.
• W2553896360 cites W2115072149 @default.
• W2553896360 cites W2130697959 @default.
• W2553896360 cites W2135886742 @default.
• W2553896360 cites W2146834306 @default.
• W2553896360 cites W2155263737 @default.
• W2553896360 cites W2155689719 @default.
• W2553896360 cites W2162519832 @default.
• W2553896360 cites W2175384111 @default.
• W2553896360 cites W2230386769 @default.
• W2553896360 cites W2460694026 @default.
• W2553896360 doi "https://doi.org/10.1186/s13550-016-0234-3" @default.
• W2553896360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5112222" @default.
• W2553896360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27854031" @default.
• W2553896360 hasPublicationYear "2016" @default.
• W2553896360 type Work @default.
• W2553896360 sameAs 2553896360 @default.
• W2553896360 citedByCount "2" @default.
• W2553896360 countsByYear W25538963602020 @default.
• W2553896360 countsByYear W25538963602021 @default.
• W2553896360 crossrefType "journal-article" @default.
• W2553896360 hasAuthorship W2553896360A5001831939 @default.
• W2553896360 hasAuthorship W2553896360A5007167001 @default.
• W2553896360 hasAuthorship W2553896360A5022281453 @default.
• W2553896360 hasAuthorship W2553896360A5023030770 @default.
• W2553896360 hasAuthorship W2553896360A5039046366 @default.
• W2553896360 hasAuthorship W2553896360A5053096526 @default.
• W2553896360 hasAuthorship W2553896360A5060311534 @default.
• W2553896360 hasAuthorship W2553896360A5070417221 @default.
• W2553896360 hasAuthorship W2553896360A5071080479 @default.
• W2553896360 hasAuthorship W2553896360A5080620533 @default.
• W2553896360 hasAuthorship W2553896360A5090126935 @default.
• W2553896360 hasBestOaLocation W25538963601 @default.
• W2553896360 hasConcept C121608353 @default.
• W2553896360 hasConcept C126322002 @default.
• W2553896360 hasConcept C126838900 @default.
• W2553896360 hasConcept C127077266 @default.
• W2553896360 hasConcept C2775842073 @default.
• W2553896360 hasConcept C2776127602 @default.
• W2553896360 hasConcept C2776694085 @default.
• W2553896360 hasConcept C2778822529 @default.
• W2553896360 hasConcept C2779984678 @default.
• W2553896360 hasConcept C2989005 @default.
• W2553896360 hasConcept C71924100 @default.
• W2553896360 hasConceptScore W2553896360C121608353 @default.
• W2553896360 hasConceptScore W2553896360C126322002 @default.
• W2553896360 hasConceptScore W2553896360C126838900 @default.
• W2553896360 hasConceptScore W2553896360C127077266 @default.
• W2553896360 hasConceptScore W2553896360C2775842073 @default.
• W2553896360 hasConceptScore W2553896360C2776127602 @default.
• W2553896360 hasConceptScore W2553896360C2776694085 @default.
• W2553896360 hasConceptScore W2553896360C2778822529 @default.
• W2553896360 hasConceptScore W2553896360C2779984678 @default.
• W2553896360 hasConceptScore W2553896360C2989005 @default.
• W2553896360 hasConceptScore W2553896360C71924100 @default.
• W2553896360 hasFunder F4320334626 @default.
• W2553896360 hasIssue "1" @default.
• W2553896360 hasLocation W25538963601 @default.
• W2553896360 hasLocation W25538963602 @default.
• W2553896360 hasLocation W25538963603 @default.
• W2553896360 hasLocation W25538963604 @default.
• W2553896360 hasOpenAccess W2553896360 @default.
• W2553896360 hasPrimaryLocation W25538963601 @default.
• W2553896360 hasRelatedWork W2054476072 @default.
• W2553896360 hasRelatedWork W2162921183 @default.

• next