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- W2553951334 abstract "Abstract The laboratory community routinely uses the assay percent coefficient of variation (CV%) as the standard measure of assay precision. This community is not accustomed to reporting results in a manner suitable for proper quantitative weighting of laboratory precision in analyzing pharmakinetic (PK) data, or any other data. The reciprocal of the assay variance of any given measurement is the correct general measure of assay precision, as is well described in many statistics books. It provides the correct measure of precision of an assay result. Witout such correct weighting of assay results, correct estimates of model parameter values will not be obtained, and correct dosage regimens for patients cannot be developed. Further, not only does reciprocal of variance provide correct weighting of assay data, but there is no need to censor low results or invent a so-called lower limit of assay quantification (LLOQ) or detection. LLOQ is now seen to be a cultural illusion brought about by the failure of CV% to function as the measurements approach zero." @default.
- W2553951334 created "2016-11-30" @default.
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- W2553951334 date "2017-01-01" @default.
- W2553951334 modified "2023-09-26" @default.
- W2553951334 title "Optimizing Laboratory Assay Methods for Individualized Therapy" @default.
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- W2553951334 doi "https://doi.org/10.1016/b978-0-12-803348-7.00004-6" @default.
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