Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554006989> ?p ?o ?g. }
- W2554006989 abstract "Histone acetylation plays key roles in gene expression, but its effects on superoxide dismutase 1 (SOD1) expression in senile cataract remains unknown. To address this problem, the study was to investigate the influence of histone acetylation on SOD1 expression and its effects in the pathogenesis of senile cataract. Senile cataract was classified into three types-nuclear cataract (NC), cortical cataract (CC), and posterior subcapsular cataract (SC)-using the Lens Opacities Classification System III. In senile cataracts, SOD1 expression decreased significantly. Both H3 and H4 were deacetylated at -600 bp of the SOD1 promoter of cataract lenses, and hypoacetylated at -1500, -1200, and -900 bp. In hypoacetylated histones, the hypoacetylation pattern differed among the cataracts. In vitro, anacardic acid (AA) significantly reduced H3 and H4 acetylation at the SOD1 promoter, decreased protein expression, and induced cataract formation in rabbits. AA also inhibited HLEC viability and increased cell apoptosis. In contrast, trichostatin A (TSA) was able to efficaciously stop AA's effects on both rabbit lenses and HLECs. Decreased histone acetylation at the SOD1 promoter is associated with declined SOD1 expression in senile cataracts. Histone acetylation plays an essential role in the regulation of SOD1 expression and in the pathogenesis of senile cataracts." @default.
- W2554006989 created "2016-11-30" @default.
- W2554006989 creator A5008636823 @default.
- W2554006989 creator A5018401236 @default.
- W2554006989 creator A5034171571 @default.
- W2554006989 creator A5038851564 @default.
- W2554006989 creator A5075338763 @default.
- W2554006989 creator A5079026276 @default.
- W2554006989 creator A5083424856 @default.
- W2554006989 date "2016-10-05" @default.
- W2554006989 modified "2023-10-16" @default.
- W2554006989 title "Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract" @default.
- W2554006989 cites W1492696318 @default.
- W2554006989 cites W1507726063 @default.
- W2554006989 cites W1756696014 @default.
- W2554006989 cites W1978104691 @default.
- W2554006989 cites W1978893041 @default.
- W2554006989 cites W1996095832 @default.
- W2554006989 cites W1998392924 @default.
- W2554006989 cites W2005446164 @default.
- W2554006989 cites W2019084941 @default.
- W2554006989 cites W2020391754 @default.
- W2554006989 cites W2023958717 @default.
- W2554006989 cites W2035524276 @default.
- W2554006989 cites W2035915355 @default.
- W2554006989 cites W2042662902 @default.
- W2554006989 cites W2048220462 @default.
- W2554006989 cites W2052443332 @default.
- W2554006989 cites W2072978915 @default.
- W2554006989 cites W2075907707 @default.
- W2554006989 cites W2078018409 @default.
- W2554006989 cites W2080039572 @default.
- W2554006989 cites W2086508531 @default.
- W2554006989 cites W2094552440 @default.
- W2554006989 cites W2096083625 @default.
- W2554006989 cites W2096923001 @default.
- W2554006989 cites W2116660385 @default.
- W2554006989 cites W2124367406 @default.
- W2554006989 cites W2129953656 @default.
- W2554006989 cites W2131331729 @default.
- W2554006989 cites W2145506361 @default.
- W2554006989 cites W2147988440 @default.
- W2554006989 cites W2157517416 @default.
- W2554006989 cites W2159130722 @default.
- W2554006989 cites W2161827767 @default.
- W2554006989 cites W2170466740 @default.
- W2554006989 cites W2198587654 @default.
- W2554006989 cites W2313860700 @default.
- W2554006989 cites W2327116398 @default.
- W2554006989 cites W2411362424 @default.
- W2554006989 cites W53507410 @default.
- W2554006989 doi "https://doi.org/10.1038/srep34704" @default.
- W2554006989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5050424" @default.
- W2554006989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27703255" @default.
- W2554006989 hasPublicationYear "2016" @default.
- W2554006989 type Work @default.
- W2554006989 sameAs 2554006989 @default.
- W2554006989 citedByCount "15" @default.
- W2554006989 countsByYear W25540069892017 @default.
- W2554006989 countsByYear W25540069892018 @default.
- W2554006989 countsByYear W25540069892019 @default.
- W2554006989 countsByYear W25540069892020 @default.
- W2554006989 countsByYear W25540069892022 @default.
- W2554006989 countsByYear W25540069892023 @default.
- W2554006989 crossrefType "journal-article" @default.
- W2554006989 hasAuthorship W2554006989A5008636823 @default.
- W2554006989 hasAuthorship W2554006989A5018401236 @default.
- W2554006989 hasAuthorship W2554006989A5034171571 @default.
- W2554006989 hasAuthorship W2554006989A5038851564 @default.
- W2554006989 hasAuthorship W2554006989A5075338763 @default.
- W2554006989 hasAuthorship W2554006989A5079026276 @default.
- W2554006989 hasAuthorship W2554006989A5083424856 @default.
- W2554006989 hasBestOaLocation W25540069891 @default.
- W2554006989 hasConcept C104317684 @default.
- W2554006989 hasConcept C118487528 @default.
- W2554006989 hasConcept C119157956 @default.
- W2554006989 hasConcept C134018914 @default.
- W2554006989 hasConcept C150194340 @default.
- W2554006989 hasConcept C153911025 @default.
- W2554006989 hasConcept C203014093 @default.
- W2554006989 hasConcept C2775838275 @default.
- W2554006989 hasConcept C2776151105 @default.
- W2554006989 hasConcept C2777615887 @default.
- W2554006989 hasConcept C2780225610 @default.
- W2554006989 hasConcept C2780942790 @default.
- W2554006989 hasConcept C3019758384 @default.
- W2554006989 hasConcept C502942594 @default.
- W2554006989 hasConcept C55493867 @default.
- W2554006989 hasConcept C64927066 @default.
- W2554006989 hasConcept C71924100 @default.
- W2554006989 hasConcept C86803240 @default.
- W2554006989 hasConceptScore W2554006989C104317684 @default.
- W2554006989 hasConceptScore W2554006989C118487528 @default.
- W2554006989 hasConceptScore W2554006989C119157956 @default.
- W2554006989 hasConceptScore W2554006989C134018914 @default.
- W2554006989 hasConceptScore W2554006989C150194340 @default.
- W2554006989 hasConceptScore W2554006989C153911025 @default.
- W2554006989 hasConceptScore W2554006989C203014093 @default.
- W2554006989 hasConceptScore W2554006989C2775838275 @default.
- W2554006989 hasConceptScore W2554006989C2776151105 @default.