FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554041793> ?p ?o ?g. }

• W2554041793 endingPage "215" @default.
• W2554041793 startingPage "209" @default.
• W2554041793 abstract "N-arachidonoyl glycine (NAGLY), is the endogenous lipid that activates the G protein-couple receptor 18 (GPR18) with vasodilatory activity in resistance arteries. This study investigates its hemodynamic effects and mechanisms of vasorelaxation. Hemodynamic effects of NAGLY in rats were assessed using a Biopac system and its vascular responses were assessed using a wire myograph. NAGLY (1 mg/kg) decreased blood pressure by 69.4±5.5% and reduced renal blood flow by 88±12% and the effects were not sensitive to inhibition by O-1918 (3 mg/kg). In resistant vessels, NAGLY (1–30 µM) induced concentration- and endothelium-dependent vasorelaxation and the effect was inhibited by the nitric oxide synthase inhibitor, L-NAME (300 µM), a cGMP synthase inhibitor, ODQ (10 µM), the antagonists of “endothelial anandamide” receptor, rimonabant (3 µM) and O-1918 (10 µM) and the inhibitor of Na+/Ca2+ exchanger (NCX), KB-R7943 (10 µM). On the other hand, NAGLY-induced vasorelaxation was not affected by CID 16020046 (GPR55 antagonist), AM 251 (cannabinoid CB1 receptor antagonist), AM 630 (cannabinoid CB2 receptor antagonist), capsazepine (TRPV1 antagonist), indomethacin (cyclooxygenase inhibitor), TRAM34 (IKCa channel blocker), iberiotoxin (BKCa channel blocker) and GW9662 (PPARɤ antagonist). At low concentrations of carbachol, NAGLY potentiated carbachol-induced vasorelaxation. NAGLY is an endothelium-dependent vasodilator and hypotensive lipid. The vasorelaxation is predominantly via activation of nitric oxide-cGMP pathway and NCX and probably mediated by the endothelial anandamide” receptor, while the hypotensive effect of NAGLY appears not to involve the anandamide receptor. NAGLY also potentiates carbachol-induced vasorelaxation, the mechanism of which might involve stimulation of NO release." @default.
• W2554041793 created "2016-11-30" @default.
• W2554041793 creator A5036115566 @default.
• W2554041793 creator A5085611504 @default.
• W2554041793 date "2017-01-01" @default.
• W2554041793 modified "2023-09-27" @default.
• W2554041793 title "The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant" @default.
• W2554041793 cites W1490160247 @default.
• W2554041793 cites W1573025737 @default.
• W2554041793 cites W157425433 @default.
• W2554041793 cites W1581998318 @default.
• W2554041793 cites W1607638275 @default.
• W2554041793 cites W1631419451 @default.
• W2554041793 cites W1670044449 @default.
• W2554041793 cites W1781620361 @default.
• W2554041793 cites W1823659570 @default.
• W2554041793 cites W1846105109 @default.
• W2554041793 cites W1965362276 @default.
• W2554041793 cites W1969453374 @default.
• W2554041793 cites W1976768202 @default.
• W2554041793 cites W1979963836 @default.
• W2554041793 cites W1989073099 @default.
• W2554041793 cites W1994430955 @default.
• W2554041793 cites W1996615067 @default.
• W2554041793 cites W1997310048 @default.
• W2554041793 cites W1998601526 @default.
• W2554041793 cites W2002445186 @default.
• W2554041793 cites W2003010360 @default.
• W2554041793 cites W2006878320 @default.
• W2554041793 cites W2009364009 @default.
• W2554041793 cites W2019892336 @default.
• W2554041793 cites W2033837348 @default.
• W2554041793 cites W2037471778 @default.
• W2554041793 cites W2044609482 @default.
• W2554041793 cites W2054168913 @default.
• W2554041793 cites W2055696035 @default.
• W2554041793 cites W2064819108 @default.
• W2554041793 cites W2068129165 @default.
• W2554041793 cites W2082730277 @default.
• W2554041793 cites W2092059778 @default.
• W2554041793 cites W2097168752 @default.
• W2554041793 cites W2098392958 @default.
• W2554041793 cites W2107658072 @default.
• W2554041793 cites W2119097555 @default.
• W2554041793 cites W2120141818 @default.
• W2554041793 cites W2135592698 @default.
• W2554041793 cites W2147929015 @default.
• W2554041793 cites W2155053157 @default.
• W2554041793 cites W2157406543 @default.
• W2554041793 cites W2163779492 @default.
• W2554041793 cites W2169214471 @default.
• W2554041793 doi "https://doi.org/10.1016/j.ejphar.2016.11.040" @default.
• W2554041793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27890711" @default.
• W2554041793 hasPublicationYear "2017" @default.
• W2554041793 type Work @default.
• W2554041793 sameAs 2554041793 @default.
• W2554041793 citedByCount "21" @default.
• W2554041793 countsByYear W25540417932017 @default.
• W2554041793 countsByYear W25540417932018 @default.
• W2554041793 countsByYear W25540417932019 @default.
• W2554041793 countsByYear W25540417932020 @default.
• W2554041793 countsByYear W25540417932021 @default.
• W2554041793 countsByYear W25540417932022 @default.
• W2554041793 countsByYear W25540417932023 @default.
• W2554041793 crossrefType "journal-article" @default.
• W2554041793 hasAuthorship W2554041793A5036115566 @default.
• W2554041793 hasAuthorship W2554041793A5085611504 @default.
• W2554041793 hasConcept C120770815 @default.
• W2554041793 hasConcept C126322002 @default.
• W2554041793 hasConcept C134018914 @default.
• W2554041793 hasConcept C148001335 @default.
• W2554041793 hasConcept C155164980 @default.
• W2554041793 hasConcept C160145004 @default.
• W2554041793 hasConcept C170493617 @default.
• W2554041793 hasConcept C178790620 @default.
• W2554041793 hasConcept C185592680 @default.
• W2554041793 hasConcept C2776885963 @default.
• W2554041793 hasConcept C2776919887 @default.
• W2554041793 hasConcept C2777622882 @default.
• W2554041793 hasConcept C2778122271 @default.
• W2554041793 hasConcept C2779783865 @default.
• W2554041793 hasConcept C2780071552 @default.
• W2554041793 hasConcept C2780433416 @default.
• W2554041793 hasConcept C519063684 @default.
• W2554041793 hasConcept C519581460 @default.
• W2554041793 hasConcept C55493867 @default.
• W2554041793 hasConcept C71924100 @default.
• W2554041793 hasConcept C98274493 @default.
• W2554041793 hasConceptScore W2554041793C120770815 @default.
• W2554041793 hasConceptScore W2554041793C126322002 @default.
• W2554041793 hasConceptScore W2554041793C134018914 @default.
• W2554041793 hasConceptScore W2554041793C148001335 @default.
• W2554041793 hasConceptScore W2554041793C155164980 @default.
• W2554041793 hasConceptScore W2554041793C160145004 @default.
• W2554041793 hasConceptScore W2554041793C170493617 @default.
• W2554041793 hasConceptScore W2554041793C178790620 @default.
• W2554041793 hasConceptScore W2554041793C185592680 @default.
• W2554041793 hasConceptScore W2554041793C2776885963 @default.

• next