FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554053906> ?p ?o ?g. }

• W2554053906 endingPage "143" @default.
• W2554053906 startingPage "134" @default.
• W2554053906 abstract "Ageing is associated with sarcopenia, a progressive decline of skeletal muscle mass, muscle quality and muscle function. Reduced sensitivity of older muscles to respond to anabolic stimuli, i.e. anabolic resistance, is part of the underlying mechanisms. Although, muscle parameters have been studied in mice of various ages/strains; the aim was to study if mice display similar deteriorating processes as human ageing. Therefore, 10,16,21 and 25 months-old C57BL6/6J male mice were studied to measure parameters of sarcopenia and factors contributing to its pathophysiology, with the aim of characterizing sarcopenia in old mice. Muscle mass of the hind limb was lower in 25 as compared to 10 month-old mice. A significant decrease in physical daily activity, muscle grip strength and ex vivo muscle maximal force production was observed in 25 compared to 10 month-old mice. The muscle anabolic response to a single protein meal showed increased muscle protein synthesis in young, but not in old mice, indicative to anabolic resistance. However, by increasing the protein content in meals, anabolic resistance could be overcome, similar as in human elderly. Additionally, aged mice showed higher fasted insulin and hepatic malondialdehyde (MDA) levels (=marker oxidative stress). This study shows clear characteristics of sarcopenia that coincide with anabolic resistance, insulin resistance and oxidative stress in 25 month-old C57/BL6 male mice, similar to human ageing. Furthermore, similar decline in muscle mass, strength and function was observed in this aged-mice-model. These observations offer potential for the future to explore in old mice the effects of interventions targeting sarcopenia." @default.
• W2554053906 created "2016-11-30" @default.
• W2554053906 creator A5009761270 @default.
• W2554053906 creator A5014787475 @default.
• W2554053906 creator A5019171913 @default.
• W2554053906 creator A5063255977 @default.
• W2554053906 creator A5074452783 @default.
• W2554053906 creator A5077394338 @default.
• W2554053906 creator A5079057017 @default.
• W2554053906 creator A5085545074 @default.
• W2554053906 date "2017-03-01" @default.
• W2554053906 modified "2023-10-07" @default.
• W2554053906 title "Sarcopenia in older mice is characterized by a decreased anabolic response to a protein meal" @default.
• W2554053906 cites W1597512020 @default.
• W2554053906 cites W1953978815 @default.
• W2554053906 cites W1965850822 @default.
• W2554053906 cites W1967010861 @default.
• W2554053906 cites W1967880601 @default.
• W2554053906 cites W1978706352 @default.
• W2554053906 cites W1982568803 @default.
• W2554053906 cites W1986042961 @default.
• W2554053906 cites W1986853038 @default.
• W2554053906 cites W1993699862 @default.
• W2554053906 cites W1999218428 @default.
• W2554053906 cites W2008936154 @default.
• W2554053906 cites W2009812367 @default.
• W2554053906 cites W2035499535 @default.
• W2554053906 cites W2035664793 @default.
• W2554053906 cites W2043280049 @default.
• W2554053906 cites W2047056169 @default.
• W2554053906 cites W2048802580 @default.
• W2554053906 cites W2048874676 @default.
• W2554053906 cites W2055142018 @default.
• W2554053906 cites W2065392210 @default.
• W2554053906 cites W2067854578 @default.
• W2554053906 cites W2070003309 @default.
• W2554053906 cites W2072998904 @default.
• W2554053906 cites W2076619740 @default.
• W2554053906 cites W2077102648 @default.
• W2554053906 cites W2082833369 @default.
• W2554053906 cites W2097772356 @default.
• W2554053906 cites W2102803403 @default.
• W2554053906 cites W2102902846 @default.
• W2554053906 cites W2104357394 @default.
• W2554053906 cites W2105199683 @default.
• W2554053906 cites W2106637677 @default.
• W2554053906 cites W2107544153 @default.
• W2554053906 cites W2110839189 @default.
• W2554053906 cites W2115150337 @default.
• W2554053906 cites W2119150168 @default.
• W2554053906 cites W2119448420 @default.
• W2554053906 cites W2119691405 @default.
• W2554053906 cites W2119711206 @default.
• W2554053906 cites W2123231624 @default.
• W2554053906 cites W2127835340 @default.
• W2554053906 cites W2129322604 @default.
• W2554053906 cites W2130861367 @default.
• W2554053906 cites W2134808941 @default.
• W2554053906 cites W2137000539 @default.
• W2554053906 cites W2137909139 @default.
• W2554053906 cites W2141224786 @default.
• W2554053906 cites W2144682732 @default.
• W2554053906 cites W2145207164 @default.
• W2554053906 cites W2145437687 @default.
• W2554053906 cites W2152045320 @default.
• W2554053906 cites W2154248702 @default.
• W2554053906 cites W2156013187 @default.
• W2554053906 cites W2158485802 @default.
• W2554053906 cites W2164782004 @default.
• W2554053906 cites W2165232899 @default.
• W2554053906 cites W2165761157 @default.
• W2554053906 cites W2166630441 @default.
• W2554053906 cites W2169057266 @default.
• W2554053906 doi "https://doi.org/10.1016/j.archger.2016.11.014" @default.
• W2554053906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27918964" @default.
• W2554053906 hasPublicationYear "2017" @default.
• W2554053906 type Work @default.
• W2554053906 sameAs 2554053906 @default.
• W2554053906 citedByCount "29" @default.
• W2554053906 countsByYear W25540539062017 @default.
• W2554053906 countsByYear W25540539062018 @default.
• W2554053906 countsByYear W25540539062019 @default.
• W2554053906 countsByYear W25540539062020 @default.
• W2554053906 countsByYear W25540539062021 @default.
• W2554053906 countsByYear W25540539062022 @default.
• W2554053906 countsByYear W25540539062023 @default.
• W2554053906 crossrefType "journal-article" @default.
• W2554053906 hasAuthorship W2554053906A5009761270 @default.
• W2554053906 hasAuthorship W2554053906A5014787475 @default.
• W2554053906 hasAuthorship W2554053906A5019171913 @default.
• W2554053906 hasAuthorship W2554053906A5063255977 @default.
• W2554053906 hasAuthorship W2554053906A5074452783 @default.
• W2554053906 hasAuthorship W2554053906A5077394338 @default.
• W2554053906 hasAuthorship W2554053906A5079057017 @default.
• W2554053906 hasAuthorship W2554053906A5085545074 @default.
• W2554053906 hasConcept C1008401 @default.
• W2554053906 hasConcept C126322002 @default.
• W2554053906 hasConcept C134018914 @default.

• next