FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554076427> ?p ?o ?g. }

• W2554076427 abstract "African-American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how APOL1 genotypes contribute to kidney disease risk, progression, and cardiovascular morbidity in children.We examined the prevalence of APOL1 genotypes and associated cardiovascular phenotypes among children with FSGS in the Chronic Kidney Disease in Children (CKiD) study; an ongoing multicenter prospective cohort study of children aged 1-16 years with mild to moderate kidney disease.A total of 140 AA children in the CKiD study were genotyped. High risk (HR) APOL1 genotypes were present in 24% of AA children (33/140) and were associated with FSGS, p < 0.001. FSGS was the most common cause of glomerular disease in children with HR APOL1 (89%; 25/28). Of 32 AA children with FSGS, 25 (78%) had HR APOL1. Compared to children with low risk APOL1 and FSGS (comprising 36 non-AA and 7 AA), children with HR APOL1 developed FSGS at a later age, 12.0 (IQR: 9.5, 12.5) vs. 5.5 (2.5, 11.5) years, p = 0.004, had a higher prevalence of uncontrolled hypertension (52 vs. 33%, p = 0.13), left ventricular hypertrophy (LVH) (53 vs. 12%, p < 0.01), C-reactive protein > 3 mg/l (33 vs. 15%, p = 0.12), and obesity (48 vs. 19%, p = 0.01). There were no differences in glomerular filtration rate, hemoglobin, iPTH, or calcium-phosphate product.AA children with HR APOL1 genotype and FSGS have increase prevalence of obesity and LVH despite a later age of FSGS onset, while adjusting for socioeconomic status. Treatment of obesity may be an important component of chronic kidney disease and LVH management in this population." @default.
• W2554076427 created "2016-11-30" @default.
• W2554076427 creator A5005791697 @default.
• W2554076427 creator A5012505167 @default.
• W2554076427 creator A5015027317 @default.
• W2554076427 creator A5020313015 @default.
• W2554076427 creator A5024733766 @default.
• W2554076427 creator A5027825347 @default.
• W2554076427 creator A5044494633 @default.
• W2554076427 creator A5056623045 @default.
• W2554076427 creator A5057786239 @default.
• W2554076427 creator A5070427332 @default.
• W2554076427 creator A5073987877 @default.
• W2554076427 creator A5082182356 @default.
• W2554076427 date "2016-11-17" @default.
• W2554076427 modified "2023-10-13" @default.
• W2554076427 title "Renal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis" @default.
• W2554076427 cites W1968177453 @default.
• W2554076427 cites W1977538400 @default.
• W2554076427 cites W1984767832 @default.
• W2554076427 cites W1997988546 @default.
• W2554076427 cites W2002359955 @default.
• W2554076427 cites W2003404235 @default.
• W2554076427 cites W2009187570 @default.
• W2554076427 cites W2010579338 @default.
• W2554076427 cites W2030803259 @default.
• W2554076427 cites W2044148002 @default.
• W2554076427 cites W2084029168 @default.
• W2554076427 cites W2090897475 @default.
• W2554076427 cites W2095763846 @default.
• W2554076427 cites W2096587435 @default.
• W2554076427 cites W2100619505 @default.
• W2554076427 cites W2101161530 @default.
• W2554076427 cites W2110453024 @default.
• W2554076427 cites W2124641083 @default.
• W2554076427 cites W2124809323 @default.
• W2554076427 cites W2137096226 @default.
• W2554076427 cites W2139691971 @default.
• W2554076427 cites W2142495742 @default.
• W2554076427 cites W2145399033 @default.
• W2554076427 cites W2145838320 @default.
• W2554076427 cites W2155960846 @default.
• W2554076427 cites W2167032249 @default.
• W2554076427 cites W2288605373 @default.
• W2554076427 cites W2343659229 @default.
• W2554076427 cites W4251458288 @default.
• W2554076427 doi "https://doi.org/10.3389/fped.2016.00122" @default.
• W2554076427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5110572" @default.
• W2554076427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27900314" @default.
• W2554076427 hasPublicationYear "2016" @default.
• W2554076427 type Work @default.
• W2554076427 sameAs 2554076427 @default.
• W2554076427 citedByCount "27" @default.
• W2554076427 countsByYear W25540764272017 @default.
• W2554076427 countsByYear W25540764272018 @default.
• W2554076427 countsByYear W25540764272019 @default.
• W2554076427 countsByYear W25540764272020 @default.
• W2554076427 countsByYear W25540764272021 @default.
• W2554076427 countsByYear W25540764272022 @default.
• W2554076427 countsByYear W25540764272023 @default.
• W2554076427 crossrefType "journal-article" @default.
• W2554076427 hasAuthorship W2554076427A5005791697 @default.
• W2554076427 hasAuthorship W2554076427A5012505167 @default.
• W2554076427 hasAuthorship W2554076427A5015027317 @default.
• W2554076427 hasAuthorship W2554076427A5020313015 @default.
• W2554076427 hasAuthorship W2554076427A5024733766 @default.
• W2554076427 hasAuthorship W2554076427A5027825347 @default.
• W2554076427 hasAuthorship W2554076427A5044494633 @default.
• W2554076427 hasAuthorship W2554076427A5056623045 @default.
• W2554076427 hasAuthorship W2554076427A5057786239 @default.
• W2554076427 hasAuthorship W2554076427A5070427332 @default.
• W2554076427 hasAuthorship W2554076427A5073987877 @default.
• W2554076427 hasAuthorship W2554076427A5082182356 @default.
• W2554076427 hasBestOaLocation W25540764271 @default.
• W2554076427 hasConcept C126322002 @default.
• W2554076427 hasConcept C134018914 @default.
• W2554076427 hasConcept C159641895 @default.
• W2554076427 hasConcept C187212893 @default.
• W2554076427 hasConcept C188816634 @default.
• W2554076427 hasConcept C2777390665 @default.
• W2554076427 hasConcept C2778415529 @default.
• W2554076427 hasConcept C2778653478 @default.
• W2554076427 hasConcept C2779561371 @default.
• W2554076427 hasConcept C2780091579 @default.
• W2554076427 hasConcept C42407357 @default.
• W2554076427 hasConcept C71924100 @default.
• W2554076427 hasConcept C90924648 @default.
• W2554076427 hasConceptScore W2554076427C126322002 @default.
• W2554076427 hasConceptScore W2554076427C134018914 @default.
• W2554076427 hasConceptScore W2554076427C159641895 @default.
• W2554076427 hasConceptScore W2554076427C187212893 @default.
• W2554076427 hasConceptScore W2554076427C188816634 @default.
• W2554076427 hasConceptScore W2554076427C2777390665 @default.
• W2554076427 hasConceptScore W2554076427C2778415529 @default.
• W2554076427 hasConceptScore W2554076427C2778653478 @default.
• W2554076427 hasConceptScore W2554076427C2779561371 @default.
• W2554076427 hasConceptScore W2554076427C2780091579 @default.
• W2554076427 hasConceptScore W2554076427C42407357 @default.
• W2554076427 hasConceptScore W2554076427C71924100 @default.
• W2554076427 hasConceptScore W2554076427C90924648 @default.

• next