FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554328259> ?p ?o ?g. }

• W2554328259 endingPage "85" @default.
• W2554328259 startingPage "77" @default.
• W2554328259 abstract "Concentration of both choline plasmalogen (PC-Pls) and ethanolamine Pls (PE-Pls) in human plasma/serum has been getting attention to, since certain patients including those with neurodegenerative disorders, have been reported to exhibit reduced levels of specific Pls species. However, despite using liquid chromatography-tandem mass spectrometry (LC-MS/MS), accurate quantitation of Pls is still difficult because of less product ion from PC-Pls and quantitative issues (e.g., extraction recoveries and matrix effects). The present study aimed to develop a method for accurate identification and quantitation of Pls molecular species using LC-MS/MS operated in the multiple reaction monitoring mode. The LC-MS/MS conditions in the presence of sodium, and the extraction method using methanol protein precipitation were optimized. Under the optimal condition, Pls was detected at femtomole levels. The recoveries of Pls from human plasma were nearly 100%, and matrix effects were not observed. The novel method enabled determination of each Pls species in human plasma at the concentrations of 0.5-13.6μM. Then the PC-Pls and PE-Pls species in the plasma of both healthy subjects and patients with Alzheimer's disease were quantitated. The method developed herein represents a powerful tool for analyzing Pls, which may provide a better understanding of their physiological roles in vivo." @default.
• W2554328259 created "2016-11-30" @default.
• W2554328259 creator A5007175114 @default.
• W2554328259 creator A5010999141 @default.
• W2554328259 creator A5033380173 @default.
• W2554328259 creator A5041856179 @default.
• W2554328259 creator A5042373488 @default.
• W2554328259 creator A5045196987 @default.
• W2554328259 creator A5047776373 @default.
• W2554328259 creator A5067636810 @default.
• W2554328259 date "2017-02-01" @default.
• W2554328259 modified "2023-09-29" @default.
• W2554328259 title "Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography–tandem mass spectrometry" @default.
• W2554328259 cites W1560871346 @default.
• W2554328259 cites W1574033922 @default.
• W2554328259 cites W1629328346 @default.
• W2554328259 cites W1814881797 @default.
• W2554328259 cites W1965526389 @default.
• W2554328259 cites W1967190893 @default.
• W2554328259 cites W1967818306 @default.
• W2554328259 cites W1968112386 @default.
• W2554328259 cites W1976858394 @default.
• W2554328259 cites W1988211561 @default.
• W2554328259 cites W2006053844 @default.
• W2554328259 cites W2006209403 @default.
• W2554328259 cites W2009296195 @default.
• W2554328259 cites W2018559681 @default.
• W2554328259 cites W2026755253 @default.
• W2554328259 cites W2034365997 @default.
• W2554328259 cites W2040826853 @default.
• W2554328259 cites W2079857213 @default.
• W2554328259 cites W2080672802 @default.
• W2554328259 cites W2087747373 @default.
• W2554328259 cites W2106558969 @default.
• W2554328259 cites W2117388188 @default.
• W2554328259 cites W2121054516 @default.
• W2554328259 cites W2166772109 @default.
• W2554328259 cites W2168526937 @default.
• W2554328259 cites W2223372642 @default.
• W2554328259 cites W2235461737 @default.
• W2554328259 cites W2300552860 @default.
• W2554328259 cites W2408038304 @default.
• W2554328259 cites W7449367 @default.
• W2554328259 doi "https://doi.org/10.1016/j.jpba.2016.11.019" @default.
• W2554328259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27888687" @default.
• W2554328259 hasPublicationYear "2017" @default.
• W2554328259 type Work @default.
• W2554328259 sameAs 2554328259 @default.
• W2554328259 citedByCount "33" @default.
• W2554328259 countsByYear W25543282592017 @default.
• W2554328259 countsByYear W25543282592018 @default.
• W2554328259 countsByYear W25543282592019 @default.
• W2554328259 countsByYear W25543282592020 @default.
• W2554328259 countsByYear W25543282592021 @default.
• W2554328259 countsByYear W25543282592022 @default.
• W2554328259 countsByYear W25543282592023 @default.
• W2554328259 crossrefType "journal-article" @default.
• W2554328259 hasAuthorship W2554328259A5007175114 @default.
• W2554328259 hasAuthorship W2554328259A5010999141 @default.
• W2554328259 hasAuthorship W2554328259A5033380173 @default.
• W2554328259 hasAuthorship W2554328259A5041856179 @default.
• W2554328259 hasAuthorship W2554328259A5042373488 @default.
• W2554328259 hasAuthorship W2554328259A5045196987 @default.
• W2554328259 hasAuthorship W2554328259A5047776373 @default.
• W2554328259 hasAuthorship W2554328259A5067636810 @default.
• W2554328259 hasConcept C162356407 @default.
• W2554328259 hasConcept C179998833 @default.
• W2554328259 hasConcept C185592680 @default.
• W2554328259 hasConcept C2777565452 @default.
• W2554328259 hasConcept C2778918659 @default.
• W2554328259 hasConcept C2779216040 @default.
• W2554328259 hasConcept C31827203 @default.
• W2554328259 hasConcept C41625074 @default.
• W2554328259 hasConcept C43617362 @default.
• W2554328259 hasConcept C4725764 @default.
• W2554328259 hasConcept C55493867 @default.
• W2554328259 hasConcept C64489805 @default.
• W2554328259 hasConcept C74774607 @default.
• W2554328259 hasConcept C95986675 @default.
• W2554328259 hasConceptScore W2554328259C162356407 @default.
• W2554328259 hasConceptScore W2554328259C179998833 @default.
• W2554328259 hasConceptScore W2554328259C185592680 @default.
• W2554328259 hasConceptScore W2554328259C2777565452 @default.
• W2554328259 hasConceptScore W2554328259C2778918659 @default.
• W2554328259 hasConceptScore W2554328259C2779216040 @default.
• W2554328259 hasConceptScore W2554328259C31827203 @default.
• W2554328259 hasConceptScore W2554328259C41625074 @default.
• W2554328259 hasConceptScore W2554328259C43617362 @default.
• W2554328259 hasConceptScore W2554328259C4725764 @default.
• W2554328259 hasConceptScore W2554328259C55493867 @default.
• W2554328259 hasConceptScore W2554328259C64489805 @default.
• W2554328259 hasConceptScore W2554328259C74774607 @default.
• W2554328259 hasConceptScore W2554328259C95986675 @default.
• W2554328259 hasLocation W25543282591 @default.
• W2554328259 hasLocation W25543282592 @default.
• W2554328259 hasOpenAccess W2554328259 @default.
• W2554328259 hasPrimaryLocation W25543282591 @default.
• W2554328259 hasRelatedWork W1969559554 @default.

• next