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• W2554329545 abstract "Both regulatory science and clinical practice rely on best available scientific data to guide decision-making. However, changes in clinical practice may be driven by numerous other factors such as cost. In this review, we reexamine noteworthy examples where pharmacogenetic testing information was added to drug labeling to explore how the available evidence, potential public health impact, and predictive utility of each pharmacogenetic biomarker impacts clinical uptake. Advances in the field of pharmacogenetics have led to new discoveries about the genetic basis for variability in drug response. The Food and Drug Administration recognizes the value of pharmacogenetic testing strategies and has been proactive about incorporating pharmacogenetic information into the labeling of both new drugs and drugs already on the market. Although some examples have readily translated to routine clinical practice, clinical uptake of genetic testing for many drugs has been limited. Both regulatory science and clinical practice rely on data-driven approaches to guide decision making; however, additional factors are also important in clinical practice that do not impact regulatory decision making, and these considerations may result in heterogeneity in clinical uptake of pharmacogenetic testing." @default.
• W2554329545 created "2016-11-30" @default.
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• W2554329545 date "2016-12-01" @default.
• W2554329545 modified "2023-09-27" @default.
• W2554329545 title "Clinical and regulatory considerations in pharmacogenetic testing" @default.
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• W2554329545 doi "https://doi.org/10.2146/ajhp160476" @default.
• W2554329545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6462817" @default.
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