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- W2554335985 abstract "Based on the 2009 EULAR recommendations for the treatment of systemic sclerosis (SSc), a complete set with attention to new therapeutic approaches was analysed and verified for clinical use. This update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and USA, two patients nominated by the pan-European patient association for SSc (FESCA), a clinical epidemiologist and 2 research fellows. All centers from the EULAR Scleroderma Trials and Research (EUSTAR) group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in sixteen recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud9s phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis, and gastrointestinal involvement. Compared with the 2009 recommendations, the 2015 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues, and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressing SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. Taken together, these updated data- and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc and add to the emerging novel therapies for the different aspects of SSc. Disclosure of Interest U. Muller-Ladner Grant/research support from: EULAR, EUSTAR, WSF" @default.
- W2554335985 created "2016-11-30" @default.
- W2554335985 creator A5088115834 @default.
- W2554335985 date "2016-06-01" @default.
- W2554335985 modified "2023-10-17" @default.
- W2554335985 title "SP0161 Latest Advances in The Treatment and Management of Systemic Sclerosis" @default.
- W2554335985 doi "https://doi.org/10.1136/annrheumdis-2016-eular.6331" @default.
- W2554335985 hasPublicationYear "2016" @default.
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