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• W2554366730 abstract "<b><i>Background:</i></b> Secretoglobin (SCGB) 3A2, a novel, lung-enriched, cytokine-like, secreted protein of small molecular weight, was demonstrated to exhibit various biological functions including anti-inflammatory, antifibrotic and growth-factor activities. Anti-inflammatory activity was uncovered using the ovalbumin-induced allergic airway inflammation model. However, further validation of this activity using knockout mice in a different allergic inflammation model is necessary in order to establish the antiallergic inflammatory role for this protein. <b><i>Methods:</i></b><i>Scgb3a2</i>-null <i>(Scgb3a2</i>^-/-<i>)</i> mice were subjected to nasal inhalation of <i>Dermatophagoides pteronyssinus</i> extract for 5 days/week for 5 consecutive weeks; control mice received nasal inhalation of saline as a comparator. Airway inflammation was assessed by histological analysis, the number of inflammatory cells and various Th2-type cytokine levels in the lungs and bronchoalveolar lavage fluids by qRT-PCR and ELISA, respectively. <b><i>Results: </i></b>Exacerbated inflammation was found in the airway of <i>Scgb3a2</i>^-/- mice subjected to house dust mite (HDM)-induced allergic airway inflammation compared with saline-treated control groups. All the inflammation end points were increased in the <i>Scgb3a2</i>^-/- mice. The <i>Ccr4</i> and <i>Ccl17</i> mRNA levels were higher in HDM-treated lungs of <i>Scgb3a2</i>^-/- mice than wild-type mice or saline-treated <i>Scgb3a2</i>^-/- mice, whereas no changes were observed for <i>Ccr3</i> and <i>Ccl11</i> mRNA levels. <b><i>Conclusions:</i></b> These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. SCGB3A2 may provide a useful tool to treat allergic airway inflammation, and further studies on the levels and function of SCGB3A2 in asthmatic patients are warranted." @default.
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• W2554366730 date "2016-01-01" @default.
• W2554366730 modified "2023-09-27" @default.
• W2554366730 title "Secretoglobin Superfamily Protein SCGB3A2 Alleviates House Dust Mite-Induced Allergic Airway Inflammation in Mice" @default.
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• W2554366730 doi "https://doi.org/10.1159/000450788" @default.
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