FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554375963> ?p ?o ?g. }

• W2554375963 endingPage "382" @default.
• W2554375963 startingPage "372" @default.
• W2554375963 abstract "The apical surface liquid (ASL) layer covers the airways and forms a first line of defense against pathogens. Maintenance of ASL volume by airway epithelia is essential for maintaining lung function. The proteolytic activation of epithelial Na+ channels is believed to be the dominating mechanism to cope with increases in ASL volumes. Alternative mechanisms, in particular increases in epithelial osmotic water permeability (Posm), have so far been regarded as rather less important. However, most studies mainly addressed immediate effects upon apical volume expansion (AVE) and increases in ASL. This study addresses the response of lung epithelia to long-term AVE. NCI-H441 cells and primary human tracheal epithelial cells, both cultivated in air-liquid interface conditions, were used as models for the lung epithelium. AVE was established by adding isotonic solution to the apical surface of differentiated lung epithelia, and time course of ASL volume restoration was assessed by the deuterium oxide dilution method. Concomitant ion transport was investigated in Ussing chambers. We identified a low resorptive state immediately after AVE, which coincided with proteolytic ion transport activation within 10-15 minutes after AVE. The main clearance of excess ASL occurred during a delayed (hours after AVE) high resorptive state, which did not correlate with ion transport activation. Instead, high resorptive state onset coincided with an increase in Posm, which depended on aquaporin up-regulation. In summary, our data demonstrate that, aside from ion transport activation, modulation of Posm is a major mechanism to compensate for long-term AVE in lung epithelia." @default.
• W2554375963 created "2016-11-30" @default.
• W2554375963 creator A5006030489 @default.
• W2554375963 creator A5015246499 @default.
• W2554375963 creator A5022205005 @default.
• W2554375963 creator A5027474720 @default.
• W2554375963 creator A5036645974 @default.
• W2554375963 creator A5057611416 @default.
• W2554375963 creator A5057799813 @default.
• W2554375963 creator A5064913810 @default.
• W2554375963 creator A5066429249 @default.
• W2554375963 creator A5073957834 @default.
• W2554375963 date "2017-03-01" @default.
• W2554375963 modified "2023-09-25" @default.
• W2554375963 title "Water Permeability Adjusts Resorption in Lung Epithelia to Increased Apical Surface Liquid Volumes" @default.
• W2554375963 cites W1486524131 @default.
• W2554375963 cites W1833515941 @default.
• W2554375963 cites W1926675678 @default.
• W2554375963 cites W1964378841 @default.
• W2554375963 cites W1970929493 @default.
• W2554375963 cites W1978028270 @default.
• W2554375963 cites W1985372182 @default.
• W2554375963 cites W1988343729 @default.
• W2554375963 cites W1994380807 @default.
• W2554375963 cites W1996048668 @default.
• W2554375963 cites W2000724701 @default.
• W2554375963 cites W2007415402 @default.
• W2554375963 cites W2012329129 @default.
• W2554375963 cites W2012887562 @default.
• W2554375963 cites W2018641902 @default.
• W2554375963 cites W2027105378 @default.
• W2554375963 cites W2029636839 @default.
• W2554375963 cites W2043728729 @default.
• W2554375963 cites W2045441113 @default.
• W2554375963 cites W2045611996 @default.
• W2554375963 cites W2052840326 @default.
• W2554375963 cites W2072421123 @default.
• W2554375963 cites W2072923159 @default.
• W2554375963 cites W2080619896 @default.
• W2554375963 cites W2082336876 @default.
• W2554375963 cites W2087203633 @default.
• W2554375963 cites W2101680623 @default.
• W2554375963 cites W2102931921 @default.
• W2554375963 cites W2108676410 @default.
• W2554375963 cites W2114067913 @default.
• W2554375963 cites W2115956096 @default.
• W2554375963 cites W2118823673 @default.
• W2554375963 cites W2120112732 @default.
• W2554375963 cites W2121683954 @default.
• W2554375963 cites W2133813097 @default.
• W2554375963 cites W2133921544 @default.
• W2554375963 cites W2136553339 @default.
• W2554375963 cites W2140268099 @default.
• W2554375963 cites W2140292027 @default.
• W2554375963 cites W2147208800 @default.
• W2554375963 cites W2149309380 @default.
• W2554375963 cites W2151770768 @default.
• W2554375963 cites W2154379804 @default.
• W2554375963 cites W2165816869 @default.
• W2554375963 cites W2168615296 @default.
• W2554375963 cites W2171010317 @default.
• W2554375963 cites W2171386529 @default.
• W2554375963 cites W2316496644 @default.
• W2554375963 doi "https://doi.org/10.1165/rcmb.2016-0161oc" @default.
• W2554375963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27814452" @default.
• W2554375963 hasPublicationYear "2017" @default.
• W2554375963 type Work @default.
• W2554375963 sameAs 2554375963 @default.
• W2554375963 citedByCount "16" @default.
• W2554375963 countsByYear W25543759632016 @default.
• W2554375963 countsByYear W25543759632018 @default.
• W2554375963 countsByYear W25543759632019 @default.
• W2554375963 countsByYear W25543759632020 @default.
• W2554375963 countsByYear W25543759632021 @default.
• W2554375963 countsByYear W25543759632022 @default.
• W2554375963 countsByYear W25543759632023 @default.
• W2554375963 crossrefType "journal-article" @default.
• W2554375963 hasAuthorship W2554375963A5006030489 @default.
• W2554375963 hasAuthorship W2554375963A5015246499 @default.
• W2554375963 hasAuthorship W2554375963A5022205005 @default.
• W2554375963 hasAuthorship W2554375963A5027474720 @default.
• W2554375963 hasAuthorship W2554375963A5036645974 @default.
• W2554375963 hasAuthorship W2554375963A5057611416 @default.
• W2554375963 hasAuthorship W2554375963A5057799813 @default.
• W2554375963 hasAuthorship W2554375963A5064913810 @default.
• W2554375963 hasAuthorship W2554375963A5066429249 @default.
• W2554375963 hasAuthorship W2554375963A5073957834 @default.
• W2554375963 hasConcept C12554922 @default.
• W2554375963 hasConcept C126322002 @default.
• W2554375963 hasConcept C185592680 @default.
• W2554375963 hasConcept C2777714996 @default.
• W2554375963 hasConcept C3018436504 @default.
• W2554375963 hasConcept C41625074 @default.
• W2554375963 hasConcept C55493867 @default.
• W2554375963 hasConcept C71924100 @default.
• W2554375963 hasConcept C86803240 @default.
• W2554375963 hasConcept C87568996 @default.
• W2554375963 hasConcept C95444343 @default.

• next