Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554398335> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2554398335 abstract "Abstract Place of allogeneic HSCT in the therapeutical strategy of CLL remains still controversial and unrelated allogeneic transplantation has to be better explored. This retrospective analysis concerned 214 patients (164 males and 50 females) who underwent allogeneic HSCT for CLL from unrelated donors (150 males and 64 females) and who were reported on EBMT registry. The median age was 49 years. Fifty two patients received bone marrow (BM) and 162 peripheral blood stem cells (PBSC) from 48 HLA mismatched and 166 HLA matched unrelated donors. Sex mismatch and ABO incompatibility were found in 33% and 52% of cases respectively. On 194 evaluated patients for conditioning, 80 received a myelo-ablative regimen, 114 a reduced intensity conditioning and a Total Boby Irradiation was performed in 70 cases. After transplant, 72 patients (37%) developed an acute GVHD grade II-IV (36% in BM patients and 37% in PBSC patients; 49% in myelo-ablative group and 28% in RIC group). On evaluated patients, a chronic GVHD was present in 61% of the patients (50% in BM patients and 67% in PBSC patients, 66% in myelo-ablative group and 63% in RIC group). With a median follow-up of 20 months, we found no significant difference for 3-year probability of Overall Survival between myelo-ablative group (59%, 46–76) and RIC group (48%, 37–63). No significant difference was observed when comparing BM and PBSC patients whatever the conditioning they received. OS was significantly better in HLA matched compared to HLA mismatched patients in RIC population (51% vs 36%, p=0.01) but not in myelo-ablative population. In multivariate analysis (table 1) studying pre and post transplantation factors, a significant impact of 2 variables, age and aGVHD (grade III-IV vs 0-I), was shown on OS for the global population, myelo-ablative and RIC groups. Other variables influenced also significantly the OS: HLA matching (global and RIC populations), sex matching (myelo-ablative and RIC), TBI (myelo-ablative group). Concerning BM and PBSC groups, we demonstrated the influence of age and aGVHD. In conclusion, besides the known influence of severe aGVHD on survival, this study points out the importance of age and HLA matching in allogeneic unrelated HSCT transplantation setting for CLL. No difference was found regarding conditioning regimen and further studies are needed to determine the most adequate regimen for this disease. Multivariate analyses Variables OS (HR) p Global population Age 1.04 (1-1.07) 0.05 HLA matching: yes vs no 0.44 (0.22-0.89) 0.02 aGVHD grade III-IV vs 0-I 1.37 (1.1-1.74) 0.01 Myelo-ablative group Age 1.07 (1-1.13) 0.04 Sex Mismatch: F to M vs F to F 6.26 (1.53-25.6) 0.01 TBI: yes vs no 16.3 (3.26-80.2) 0.0006 aGVHD grade III-IV vs 0-I 1.9 (1.18-3.06) 0.008 RIC group Age 1.05 (1-1.1) 0.05 HLA matching: yes vs no 0.28 (0.1-0.76) 0.01 Sex Mismatch M to F vs F to F 0.63 (0.42-0.96) 0.03 aGVHD grade III-IV vs 0-I 1.66 (1.16-2.39) 0.005 BM group Age 1.12 (1-1.24) 0.03 aGVHD grade III-IV vs 0-I 1.88 (1-1.36) 0.05 PBSC group aGVHD grade III-IV vs 0-I 1.38 (1.02-1.86) 0.03" @default.
- W2554398335 created "2016-11-30" @default.
- W2554398335 creator A5035222674 @default.
- W2554398335 creator A5042734609 @default.
- W2554398335 creator A5055128673 @default.
- W2554398335 creator A5058677948 @default.
- W2554398335 creator A5072027146 @default.
- W2554398335 creator A5085132315 @default.
- W2554398335 creator A5085146093 @default.
- W2554398335 creator A5087870886 @default.
- W2554398335 date "2005-11-16" @default.
- W2554398335 modified "2023-10-14" @default.
- W2554398335 title "Transplant Outcome of Unrelated Hematopoietic Stem Cell Transplantation (HSCT) after Myelo-Ablative or Reduced Intensity Conditioning (RIC) for Chronic Lymphocytic Leukemia(CLL). A Study of EBMT Registry." @default.
- W2554398335 doi "https://doi.org/10.1182/blood.v106.11.561.561" @default.
- W2554398335 hasPublicationYear "2005" @default.
- W2554398335 type Work @default.
- W2554398335 sameAs 2554398335 @default.
- W2554398335 citedByCount "3" @default.
- W2554398335 crossrefType "journal-article" @default.
- W2554398335 hasAuthorship W2554398335A5035222674 @default.
- W2554398335 hasAuthorship W2554398335A5042734609 @default.
- W2554398335 hasAuthorship W2554398335A5055128673 @default.
- W2554398335 hasAuthorship W2554398335A5058677948 @default.
- W2554398335 hasAuthorship W2554398335A5072027146 @default.
- W2554398335 hasAuthorship W2554398335A5085132315 @default.
- W2554398335 hasAuthorship W2554398335A5085146093 @default.
- W2554398335 hasAuthorship W2554398335A5087870886 @default.
- W2554398335 hasConcept C126322002 @default.
- W2554398335 hasConcept C141071460 @default.
- W2554398335 hasConcept C2776694085 @default.
- W2554398335 hasConcept C2776755627 @default.
- W2554398335 hasConcept C2777408962 @default.
- W2554398335 hasConcept C2777938653 @default.
- W2554398335 hasConcept C2778461978 @default.
- W2554398335 hasConcept C2778880498 @default.
- W2554398335 hasConcept C2779263901 @default.
- W2554398335 hasConcept C2908647359 @default.
- W2554398335 hasConcept C2911091166 @default.
- W2554398335 hasConcept C71924100 @default.
- W2554398335 hasConcept C90924648 @default.
- W2554398335 hasConcept C99454951 @default.
- W2554398335 hasConceptScore W2554398335C126322002 @default.
- W2554398335 hasConceptScore W2554398335C141071460 @default.
- W2554398335 hasConceptScore W2554398335C2776694085 @default.
- W2554398335 hasConceptScore W2554398335C2776755627 @default.
- W2554398335 hasConceptScore W2554398335C2777408962 @default.
- W2554398335 hasConceptScore W2554398335C2777938653 @default.
- W2554398335 hasConceptScore W2554398335C2778461978 @default.
- W2554398335 hasConceptScore W2554398335C2778880498 @default.
- W2554398335 hasConceptScore W2554398335C2779263901 @default.
- W2554398335 hasConceptScore W2554398335C2908647359 @default.
- W2554398335 hasConceptScore W2554398335C2911091166 @default.
- W2554398335 hasConceptScore W2554398335C71924100 @default.
- W2554398335 hasConceptScore W2554398335C90924648 @default.
- W2554398335 hasConceptScore W2554398335C99454951 @default.
- W2554398335 hasLocation W25543983351 @default.
- W2554398335 hasOpenAccess W2554398335 @default.
- W2554398335 hasPrimaryLocation W25543983351 @default.
- W2554398335 hasRelatedWork W1955322177 @default.
- W2554398335 hasRelatedWork W1981025559 @default.
- W2554398335 hasRelatedWork W2027157479 @default.
- W2554398335 hasRelatedWork W2300788406 @default.
- W2554398335 hasRelatedWork W2538500352 @default.
- W2554398335 hasRelatedWork W2593968947 @default.
- W2554398335 hasRelatedWork W2609272607 @default.
- W2554398335 hasRelatedWork W2979597750 @default.
- W2554398335 hasRelatedWork W3003271891 @default.
- W2554398335 hasRelatedWork W3213199609 @default.
- W2554398335 isParatext "false" @default.
- W2554398335 isRetracted "false" @default.
- W2554398335 magId "2554398335" @default.
- W2554398335 workType "article" @default.