Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554405501> ?p ?o ?g. }
- W2554405501 endingPage "1653" @default.
- W2554405501 startingPage "1645" @default.
- W2554405501 abstract "Aggregates of amyloidogenic peptides are involved in the pathogenesis of several degenerative disorders. Herein, an iridium(III) complex, Ir-1, is reported as a chemical tool for oxidizing amyloidogenic peptides upon photoactivation and subsequently modulating their aggregation pathways. Ir-1 was rationally designed based on multiple characteristics, including 1) photoproperties leading to excitation by low-energy radiation; 2) generation of reactive oxygen species responsible for peptide oxidation upon photoactivation under mild conditions; and 3) relatively easy incorporation of a ligand on the IrIII center for specific interactions with amyloidogenic peptides. Biochemical and biophysical investigations illuminate that the oxidation of representative amyloidogenic peptides (i.e., amyloid-β, α-synuclein, and human islet amyloid polypeptide) is promoted by light-activated Ir-1, which alters the conformations and aggregation pathways of the peptides. Additionally, their potential oxidation sites are identified as methionine, histidine, or tyrosine residues. Overall, our studies on Ir-1 demonstrate the feasibility of devising metal complexes as chemical tools suitable for elucidating the nature of amyloidogenic peptides at the molecular level, as well as controlling their aggregation." @default.
- W2554405501 created "2016-11-30" @default.
- W2554405501 creator A5003930745 @default.
- W2554405501 creator A5008307832 @default.
- W2554405501 creator A5023832222 @default.
- W2554405501 creator A5027470004 @default.
- W2554405501 creator A5032576632 @default.
- W2554405501 creator A5034098044 @default.
- W2554405501 creator A5043754836 @default.
- W2554405501 creator A5049147819 @default.
- W2554405501 creator A5049472828 @default.
- W2554405501 creator A5077980720 @default.
- W2554405501 creator A5078853188 @default.
- W2554405501 creator A5079215279 @default.
- W2554405501 date "2017-01-03" @default.
- W2554405501 modified "2023-09-25" @default.
- W2554405501 title "An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation" @default.
- W2554405501 cites W1423566601 @default.
- W2554405501 cites W1572679174 @default.
- W2554405501 cites W1648265574 @default.
- W2554405501 cites W1680110353 @default.
- W2554405501 cites W1892757911 @default.
- W2554405501 cites W1965863026 @default.
- W2554405501 cites W1972520607 @default.
- W2554405501 cites W1972888996 @default.
- W2554405501 cites W1973476737 @default.
- W2554405501 cites W1980584256 @default.
- W2554405501 cites W1992505804 @default.
- W2554405501 cites W1993736701 @default.
- W2554405501 cites W1999643597 @default.
- W2554405501 cites W2000220646 @default.
- W2554405501 cites W2003511766 @default.
- W2554405501 cites W2017836578 @default.
- W2554405501 cites W2018491028 @default.
- W2554405501 cites W2019302540 @default.
- W2554405501 cites W2019812098 @default.
- W2554405501 cites W2019898105 @default.
- W2554405501 cites W2023850224 @default.
- W2554405501 cites W2026875674 @default.
- W2554405501 cites W2032903886 @default.
- W2554405501 cites W2039388940 @default.
- W2554405501 cites W2039679375 @default.
- W2554405501 cites W2041173360 @default.
- W2554405501 cites W2041202903 @default.
- W2554405501 cites W2042742422 @default.
- W2554405501 cites W2046705003 @default.
- W2554405501 cites W2047439630 @default.
- W2554405501 cites W2051829844 @default.
- W2554405501 cites W2052135535 @default.
- W2554405501 cites W2060771597 @default.
- W2554405501 cites W2062820102 @default.
- W2554405501 cites W2067814874 @default.
- W2554405501 cites W2068046340 @default.
- W2554405501 cites W2071692831 @default.
- W2554405501 cites W2076660104 @default.
- W2554405501 cites W2077273627 @default.
- W2554405501 cites W2078450707 @default.
- W2554405501 cites W2080480885 @default.
- W2554405501 cites W2084513527 @default.
- W2554405501 cites W2084885918 @default.
- W2554405501 cites W2086021375 @default.
- W2554405501 cites W2114078421 @default.
- W2554405501 cites W2118841138 @default.
- W2554405501 cites W2119783360 @default.
- W2554405501 cites W2124531971 @default.
- W2554405501 cites W2141852179 @default.
- W2554405501 cites W2148225540 @default.
- W2554405501 cites W2148599950 @default.
- W2554405501 cites W2150017596 @default.
- W2554405501 cites W2151565077 @default.
- W2554405501 cites W2152951933 @default.
- W2554405501 cites W2155767431 @default.
- W2554405501 cites W2156012420 @default.
- W2554405501 cites W2159710923 @default.
- W2554405501 cites W2161876271 @default.
- W2554405501 cites W2165021720 @default.
- W2554405501 cites W2165186407 @default.
- W2554405501 cites W2197833498 @default.
- W2554405501 cites W2222001997 @default.
- W2554405501 cites W2233924119 @default.
- W2554405501 cites W2253997490 @default.
- W2554405501 cites W2313217669 @default.
- W2554405501 cites W2322725454 @default.
- W2554405501 cites W2324279107 @default.
- W2554405501 cites W2472664892 @default.
- W2554405501 cites W2510892825 @default.
- W2554405501 cites W2530872078 @default.
- W2554405501 cites W2575449201 @default.
- W2554405501 cites W2952786326 @default.
- W2554405501 cites W4233320042 @default.
- W2554405501 cites W4247705075 @default.
- W2554405501 cites W4248954655 @default.
- W2554405501 cites W4296154147 @default.
- W2554405501 doi "https://doi.org/10.1002/chem.201604751" @default.
- W2554405501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5828235" @default.
- W2554405501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27862428" @default.
- W2554405501 hasPublicationYear "2017" @default.
- W2554405501 type Work @default.