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- W2554436040 abstract "Asthma and COPD exert a substantial economic and humanistic burden on society, with newer drugs increasingly adding to the burden. . Health economic models used to establish the differential value of newer drugs are often used, but infrequently reviewed. We synthesized evidence pertaining to economic models drugs treating asthma or chronic obstructive pulmonary disease (COPD). Comprehensive search strategies containing terms “Chronic Obstructive”, OR “asthma”, AND “economic models”, and combinations thereof were devised and were used to search Pubmed. The data pertaining to validation methods, treatments compared, analytic perspective, time horizon, input ranges, costs, sensitivity analyses were abstracted. The studies were also critically evaluated using quality of health economic scale (QHES) to determine the methodological appropriateness, robustness of the parameters and other attributes of the model. Evidence was synthesized from 39 and 14 articles associated with asthma and COPD respectively. Economic evaluations included predictive decision-analytic type models, decision trees, and Markov models. Validation of the models regarding internal, external or predictive validity was not frequently reported. The QHES score ranged from 70 to 95, indicating moderate to good quality of the decision analytic evaluations. The overarching evidence indicated a need for empirical decision analytic models suited to closely replicate clinical progression and capture economic/budgetary impact of novel therapies. Current economic models possess moderate to good quality of decision analytics. It remains to be seen whether there could be further improvements in the newer models." @default.
- W2554436040 created "2016-11-30" @default.
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- W2554436040 date "2016-09-01" @default.
- W2554436040 modified "2023-09-28" @default.
- W2554436040 title "Decision analytic models in COPD/asthma: A critical review of current evidence" @default.
- W2554436040 doi "https://doi.org/10.1183/13993003.congress-2016.pa1532" @default.
- W2554436040 hasPublicationYear "2016" @default.
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