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• W2554444237 endingPage "1973" @default.
• W2554444237 startingPage "1973" @default.
• W2554444237 abstract "Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body fluids and tissues of patients with neurodegenerative diseases and trigger microglial dysfunction involved in neurodegeneration. It is therefore important to identify synthetic and natural molecules able to impair the toxic effects of 7KC. We determined the impact of 7KC on murine microglial BV-2 cells, especially its ability to trigger mitochondrial and peroxisomal dysfunction, and evaluated the protective effects of α- and γ-tocopherol, Trolox, and oleic acid (OA). Multiple complementary chemical assays, flow cytometric and biochemical methods were used to evaluate the antioxidant and cytoprotective properties of these molecules. According to various complementary assays to estimate antioxidant activity, only α-, and γ-tocopherol, and Trolox had antioxidant properties. However, only α-tocopherol, γ-tocopherol and OA were able to impair 7KC-induced loss of mitochondrial transmembrane potential, which is associated with increased permeability to propidium iodide, an indicator of cell death. In addition, α-and γ-tocopherol, and OA were able to prevent the decrease in Abcd3 protein levels, which allows the measurement of peroxisomal mass, and in mRNA levels of Abcd1 and Abcd2, which encode for two transporters involved in peroxisomal β-oxidation. Thus, 7KC-induced side effects are associated with mitochondrial and peroxisomal dysfunction which can be inversed by natural compounds, thus supporting the hypothesis that the composition of the diet can act on the function of organelles involved in neurodegenerative diseases." @default.
• W2554444237 created "2016-11-30" @default.
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• W2554444237 date "2016-11-25" @default.
• W2554444237 modified "2023-10-14" @default.
• W2554444237 title "Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells" @default.
• W2554444237 cites W1225123808 @default.
• W2554444237 cites W1488851638 @default.
• W2554444237 cites W1493890929 @default.
• W2554444237 cites W1522739755 @default.
• W2554444237 cites W1527874749 @default.
• W2554444237 cites W1532082124 @default.
• W2554444237 cites W1613671145 @default.
• W2554444237 cites W1768846296 @default.
• W2554444237 cites W1924236635 @default.
• W2554444237 cites W1936108334 @default.
• W2554444237 cites W1941562583 @default.
• W2554444237 cites W1948224189 @default.
• W2554444237 cites W1948714265 @default.
• W2554444237 cites W1964164432 @default.
• W2554444237 cites W1971556290 @default.
• W2554444237 cites W1971817019 @default.
• W2554444237 cites W1972548733 @default.
• W2554444237 cites W1976898859 @default.
• W2554444237 cites W1981448470 @default.
• W2554444237 cites W1982673008 @default.
• W2554444237 cites W1983176088 @default.
• W2554444237 cites W1984279741 @default.
• W2554444237 cites W1986958825 @default.
• W2554444237 cites W1988292100 @default.
• W2554444237 cites W1993720376 @default.
• W2554444237 cites W2003003181 @default.
• W2554444237 cites W2006135287 @default.
• W2554444237 cites W2008773559 @default.
• W2554444237 cites W2011006393 @default.
• W2554444237 cites W2012621840 @default.
• W2554444237 cites W2015050725 @default.
• W2554444237 cites W2021995332 @default.
• W2554444237 cites W2022057737 @default.
• W2554444237 cites W2024809782 @default.
• W2554444237 cites W2026213230 @default.
• W2554444237 cites W2027065972 @default.
• W2554444237 cites W2030330491 @default.
• W2554444237 cites W2031128806 @default.
• W2554444237 cites W2031934833 @default.
• W2554444237 cites W2035189257 @default.
• W2554444237 cites W2035245572 @default.
• W2554444237 cites W2035829439 @default.
• W2554444237 cites W2039294355 @default.
• W2554444237 cites W2040365013 @default.
• W2554444237 cites W2042943797 @default.
• W2554444237 cites W2045621596 @default.
• W2554444237 cites W2047171151 @default.
• W2554444237 cites W2047418817 @default.
• W2554444237 cites W2051938843 @default.
• W2554444237 cites W2056993355 @default.
• W2554444237 cites W2060722219 @default.
• W2554444237 cites W2061450441 @default.
• W2554444237 cites W2062534385 @default.
• W2554444237 cites W2063072550 @default.
• W2554444237 cites W2063397751 @default.
• W2554444237 cites W2069789444 @default.
• W2554444237 cites W2073874316 @default.
• W2554444237 cites W2078815621 @default.
• W2554444237 cites W2080927052 @default.
• W2554444237 cites W2081597336 @default.
• W2554444237 cites W2081981367 @default.
• W2554444237 cites W2083416982 @default.
• W2554444237 cites W2084192822 @default.
• W2554444237 cites W2085917831 @default.
• W2554444237 cites W2086537933 @default.
• W2554444237 cites W2091083766 @default.
• W2554444237 cites W2094110309 @default.
• W2554444237 cites W2094168063 @default.
• W2554444237 cites W2095536240 @default.
• W2554444237 cites W2096407545 @default.
• W2554444237 cites W2100563287 @default.
• W2554444237 cites W2101061603 @default.
• W2554444237 cites W2101641567 @default.
• W2554444237 cites W2102662396 @default.
• W2554444237 cites W2112423730 @default.

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