Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554540365> ?p ?o ?g. }
- W2554540365 endingPage "52" @default.
- W2554540365 startingPage "39" @default.
- W2554540365 abstract "Mammalian cells recognize virus-derived nucleic acids using a defined set of intracellular sensors including the DNA sensors cyclic GMP-AMP (cGAMP) synthase (cGAS) and interferon gamma (IFNγ)-inducible protein 16 (IFI16) as well as viral RNA receptors of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family. Following innate immune recognition, these sensors launch an immune response that is characterized by the transcriptional upregulation of many antiviral molecules, including proinflammatory cytokines, chemokines, and IFN-stimulated genes. Recent studies have demonstrated that the signal transduction initiated by these sensors is sophisticatedly regulated by post-translational modifications (PTMs) resulting in a robust yet 'tunable' cytokine response to maintain immune homeostasis. Here we summarize recent advances in our understanding of how PTMs and regulatory enzymes control the signaling activity of RLRs, cGAS, and IFI16 as well as their proximal adaptor proteins." @default.
- W2554540365 created "2016-11-30" @default.
- W2554540365 creator A5016975145 @default.
- W2554540365 creator A5048117997 @default.
- W2554540365 date "2017-01-01" @default.
- W2554540365 modified "2023-10-01" @default.
- W2554540365 title "Post-translational Control of Intracellular Pathogen Sensing Pathways" @default.
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