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- W2554549720 abstract "Anaplastic large cell lymphoma (ALCL) is a biologic and clinically heterogeneous subtype of T-cell lymphoma, which may present as localized (primary) cutaneous disease or widespread systemic disease. Primary cutaneous ALCL (C-ALCL) is part of a spectrum of CD30+ lymphoproliferative diseases of the skin with excellent prognosis. HTLV-1-associated lymphomas include adult T-cell lymphoma and leukemia (ATL), which is characterized by a clonal expansion of CD4+ T lymphocytes frequently associated with skin rash, lymph node and visceral involvement, and hypercalcemia. ATL rarely resembles ALCL and CD30 positive. We report a patient with single ulcerative skin mass lesion which showed an ALCL in biopsy, and immunohistochemistry analysis revealed that cells expressed CD30 positive. He did not respond to systemic therapy, and in this setting I found that he is anti-HTLV1 positive. I added zidovudin and interferon to his chemotherapy but he did not response again. Skin mass was completely resolved with local radiation, but he had systemic relapse after 3-4 month and finally died because of disease severity and treatment complication. Due to the various presentations of cutaneous T-cell lymphoma which we cannot exactly classify, there is a strong need for more data and a revision of the original classification." @default.
- W2554549720 created "2016-11-30" @default.
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- W2554549720 date "2015-01-01" @default.
- W2554549720 modified "2023-09-26" @default.
- W2554549720 title "Rare Presentation of Anaplastic Large Cell Lymphoma and HTLV1 Positivity: A Case Report and Review" @default.
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