Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554585220> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2554585220 endingPage "246" @default.
- W2554585220 startingPage "229" @default.
- W2554585220 abstract "Promising pharmaceuticals frequently fail clinical trials due to cardiotoxicity or a decline in heart function not indicated from preclinical animal models and in vitro tests. The development of low-cost, high-throughput, and reliable in vitro human models remains a priority for pharmaceutical companies to avoid costly dead ends in clinical trials. Organ-on-a-chip systems allow the creation of functional, human tissue test beds that leverage the benefits of miniaturization using Biomicroelectromechanical System (BioMEMS) devices and the availability of differentiable human stem cells. We have developed a 2D cardiac platform that allows the functional interrogation of human embryonic stem cell (hESC)-derived cardiomyocytes. The platform uses a laser to reflect off silicon cantilevers with adhered cardiomyocytes to monitor the contraction-induced deflection, enabling the calculation of contractile force. Chips with up to 32 cantilevers can be scanned by an automated stage sending the cardiac signals to a high-speed detector that can record the spatial coordinates and transform them into force output. Separately, electrical conduction can also be monitored by patterning cardiomyocytes on top of microelectrode arrays. This platform enables physiologic characterization of inherited cardiomyopathies, as well as acute and chronic drug studies with arrhythmogenic and inotropic compounds, to predict their effect on in vivo cardiac output, as well as general toxicological evaluations." @default.
- W2554585220 created "2016-11-30" @default.
- W2554585220 creator A5001193839 @default.
- W2554585220 creator A5022104647 @default.
- W2554585220 creator A5026618894 @default.
- W2554585220 creator A5034545961 @default.
- W2554585220 creator A5037097714 @default.
- W2554585220 creator A5046101625 @default.
- W2554585220 creator A5060083048 @default.
- W2554585220 creator A5071212163 @default.
- W2554585220 creator A5077870897 @default.
- W2554585220 creator A5084965465 @default.
- W2554585220 date "2016-11-26" @default.
- W2554585220 modified "2023-09-27" @default.
- W2554585220 title "Contractile Force Readout of hESC-Cardiomyocytes" @default.
- W2554585220 cites W1967105697 @default.
- W2554585220 cites W1981289417 @default.
- W2554585220 cites W1991635000 @default.
- W2554585220 cites W1994104218 @default.
- W2554585220 cites W1998078072 @default.
- W2554585220 cites W1998220531 @default.
- W2554585220 cites W2004542031 @default.
- W2554585220 cites W2031383358 @default.
- W2554585220 cites W2052637617 @default.
- W2554585220 cites W2090197816 @default.
- W2554585220 cites W2098484296 @default.
- W2554585220 cites W2113927644 @default.
- W2554585220 cites W241683524 @default.
- W2554585220 doi "https://doi.org/10.1007/978-1-4939-6661-5_12" @default.
- W2554585220 hasPublicationYear "2016" @default.
- W2554585220 type Work @default.
- W2554585220 sameAs 2554585220 @default.
- W2554585220 citedByCount "3" @default.
- W2554585220 countsByYear W25545852202019 @default.
- W2554585220 countsByYear W25545852202020 @default.
- W2554585220 countsByYear W25545852202023 @default.
- W2554585220 crossrefType "book-chapter" @default.
- W2554585220 hasAuthorship W2554585220A5001193839 @default.
- W2554585220 hasAuthorship W2554585220A5022104647 @default.
- W2554585220 hasAuthorship W2554585220A5026618894 @default.
- W2554585220 hasAuthorship W2554585220A5034545961 @default.
- W2554585220 hasAuthorship W2554585220A5037097714 @default.
- W2554585220 hasAuthorship W2554585220A5046101625 @default.
- W2554585220 hasAuthorship W2554585220A5060083048 @default.
- W2554585220 hasAuthorship W2554585220A5071212163 @default.
- W2554585220 hasAuthorship W2554585220A5077870897 @default.
- W2554585220 hasAuthorship W2554585220A5084965465 @default.
- W2554585220 hasConcept C126322002 @default.
- W2554585220 hasConcept C136229726 @default.
- W2554585220 hasConcept C171250308 @default.
- W2554585220 hasConcept C192562407 @default.
- W2554585220 hasConcept C2776694085 @default.
- W2554585220 hasConcept C2778233292 @default.
- W2554585220 hasConcept C41008148 @default.
- W2554585220 hasConcept C71924100 @default.
- W2554585220 hasConceptScore W2554585220C126322002 @default.
- W2554585220 hasConceptScore W2554585220C136229726 @default.
- W2554585220 hasConceptScore W2554585220C171250308 @default.
- W2554585220 hasConceptScore W2554585220C192562407 @default.
- W2554585220 hasConceptScore W2554585220C2776694085 @default.
- W2554585220 hasConceptScore W2554585220C2778233292 @default.
- W2554585220 hasConceptScore W2554585220C41008148 @default.
- W2554585220 hasConceptScore W2554585220C71924100 @default.
- W2554585220 hasLocation W25545852201 @default.
- W2554585220 hasOpenAccess W2554585220 @default.
- W2554585220 hasPrimaryLocation W25545852201 @default.
- W2554585220 hasRelatedWork W1994696362 @default.
- W2554585220 hasRelatedWork W1995515455 @default.
- W2554585220 hasRelatedWork W2080531066 @default.
- W2554585220 hasRelatedWork W2748952813 @default.
- W2554585220 hasRelatedWork W2899084033 @default.
- W2554585220 hasRelatedWork W2998970160 @default.
- W2554585220 hasRelatedWork W3031052312 @default.
- W2554585220 hasRelatedWork W3032375762 @default.
- W2554585220 hasRelatedWork W3108674512 @default.
- W2554585220 hasRelatedWork W3125839593 @default.
- W2554585220 isParatext "false" @default.
- W2554585220 isRetracted "false" @default.
- W2554585220 magId "2554585220" @default.
- W2554585220 workType "book-chapter" @default.